FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020129712> ?p ?o ?g. }

• W2020129712 endingPage "485" @default.
• W2020129712 startingPage "480" @default.
• W2020129712 abstract "Pregabalin, an anticonvulsant and anxiolytic compound that binds to α2-δ auxiliary subunit Types 1 and 2 of voltage-gated calcium channels, has been shown to reduce excitatory neurotransmission partially through modulation of glutamatergic signaling. Prepulse inhibition (PPI) of startle is an operational measure of sensorimotor gating impacted by disruption of the glutamatergic system and is reduced in schizophrenia patients. Dysregulation of the glutamatergic system has also been implicated in the pathophysiology of schizophrenia. Here we tested the hypothesis that pregabalin may ameliorate PPI in a model of deficient gating in humans and mice. In study 1, 14 healthy human subjects participated in a within subjects, cross-over study with placebo, 50 mg or 200 mg pregabalin treatment prior to undergoing a PPI task. In study 2, 24 C57BL/6 mice underwent a similar procedure with vehicle, 30 and 100 mg/kg dose treatments. In both studies, subjects were assigned to a “Low” or “High” gating group using a median split procedure based on their PPI performance during placebo/vehicle. Drug effects were then examined across these groups. In humans, pregabalin treatment significantly increased PPI performance in the “low gating” group. In mice, pregabalin treatment significantly increased PPI in the low gating group but reduced PPI in the high gating group. Across species, pregabalin treatment improves PPI in subjects with low gating. These data support further exploration of pregabalin as a potential treatment for disorders characterized by sensorimotor gating deficits and glutamatergic hypersignaling, such as schizophrenia." @default.
• W2020129712 created "2016-06-24" @default.
• W2020129712 creator A5020426939 @default.
• W2020129712 creator A5034576114 @default.
• W2020129712 creator A5044262294 @default.
• W2020129712 creator A5067585567 @default.
• W2020129712 creator A5074969156 @default.
• W2020129712 date "2012-09-01" @default.
• W2020129712 modified "2023-10-16" @default.
• W2020129712 title "The effect of pregabalin on sensorimotor gating in ‘low’ gating humans and mice" @default.
• W2020129712 cites W1505441000 @default.
• W2020129712 cites W1966837018 @default.
• W2020129712 cites W1968840456 @default.
• W2020129712 cites W1972035205 @default.
• W2020129712 cites W1979996794 @default.
• W2020129712 cites W1984305433 @default.
• W2020129712 cites W1985310141 @default.
• W2020129712 cites W1990888488 @default.
• W2020129712 cites W1993639998 @default.
• W2020129712 cites W1997048153 @default.
• W2020129712 cites W1998766608 @default.
• W2020129712 cites W1998820576 @default.
• W2020129712 cites W2010197292 @default.
• W2020129712 cites W2011913908 @default.
• W2020129712 cites W2013514700 @default.
• W2020129712 cites W2020068013 @default.
• W2020129712 cites W2020140782 @default.
• W2020129712 cites W2021014490 @default.
• W2020129712 cites W2027215951 @default.
• W2020129712 cites W2031004040 @default.
• W2020129712 cites W2034101922 @default.
• W2020129712 cites W2040090469 @default.
• W2020129712 cites W2047187993 @default.
• W2020129712 cites W2052574348 @default.
• W2020129712 cites W2054471938 @default.
• W2020129712 cites W2059212626 @default.
• W2020129712 cites W2061939077 @default.
• W2020129712 cites W2062472783 @default.
• W2020129712 cites W2063170700 @default.
• W2020129712 cites W2067071072 @default.
• W2020129712 cites W2068847058 @default.
• W2020129712 cites W2070493747 @default.
• W2020129712 cites W2078977508 @default.
• W2020129712 cites W2080073833 @default.
• W2020129712 cites W2080119794 @default.
• W2020129712 cites W2080477042 @default.
• W2020129712 cites W2080942999 @default.
• W2020129712 cites W2081224446 @default.
• W2020129712 cites W2081677225 @default.
• W2020129712 cites W2083311772 @default.
• W2020129712 cites W2083553109 @default.
• W2020129712 cites W2089279096 @default.
• W2020129712 cites W2090979638 @default.
• W2020129712 cites W2092337985 @default.
• W2020129712 cites W2097759310 @default.
• W2020129712 cites W2107373225 @default.
• W2020129712 cites W2108011152 @default.
• W2020129712 cites W2112075082 @default.
• W2020129712 cites W2114881210 @default.
• W2020129712 cites W2116837408 @default.
• W2020129712 cites W2116896173 @default.
• W2020129712 cites W2124389210 @default.
• W2020129712 cites W2147061309 @default.
• W2020129712 cites W2150575337 @default.
• W2020129712 cites W2155757287 @default.
• W2020129712 cites W2169081020 @default.
• W2020129712 cites W2318903872 @default.
• W2020129712 cites W2324232611 @default.
• W2020129712 cites W4302309364 @default.
• W2020129712 cites W1997317927 @default.
• W2020129712 doi "https://doi.org/10.1016/j.neuropharm.2012.04.018" @default.
• W2020129712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3572212" @default.
• W2020129712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22575075" @default.
• W2020129712 hasPublicationYear "2012" @default.
• W2020129712 type Work @default.
• W2020129712 sameAs 2020129712 @default.
• W2020129712 citedByCount "17" @default.
• W2020129712 countsByYear W20201297122012 @default.
• W2020129712 countsByYear W20201297122013 @default.
• W2020129712 countsByYear W20201297122014 @default.
• W2020129712 countsByYear W20201297122015 @default.
• W2020129712 countsByYear W20201297122019 @default.
• W2020129712 countsByYear W20201297122020 @default.
• W2020129712 countsByYear W20201297122021 @default.
• W2020129712 countsByYear W20201297122022 @default.
• W2020129712 countsByYear W20201297122023 @default.
• W2020129712 crossrefType "journal-article" @default.
• W2020129712 hasAuthorship W2020129712A5020426939 @default.
• W2020129712 hasAuthorship W2020129712A5034576114 @default.
• W2020129712 hasAuthorship W2020129712A5044262294 @default.
• W2020129712 hasAuthorship W2020129712A5067585567 @default.
• W2020129712 hasAuthorship W2020129712A5074969156 @default.
• W2020129712 hasBestOaLocation W20201297122 @default.
• W2020129712 hasConcept C118552586 @default.
• W2020129712 hasConcept C126322002 @default.
• W2020129712 hasConcept C141421786 @default.
• W2020129712 hasConcept C15744967 @default.
• W2020129712 hasConcept C169760540 @default.

• next