Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020133142> ?p ?o ?g. }
- W2020133142 endingPage "152" @default.
- W2020133142 startingPage "139" @default.
- W2020133142 abstract "The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous. Three major pathways showing abnormality of intracellular metabolism have been identified in the development of diabetic nephropathy: (i) the activation of polyol and PKC (protein kinase C) pathways; (ii) the formation of advanced glycation end-products; and (iii) intraglomerular hypertension induced by glomerular hyperfiltration. Upstream of these three major pathways, hyperglycaemia is the major driving force of the progression to ESRD from diabetic nephropathy. Downstream of the three pathways, microinflammation and subsequent extracellular matrix expansion are common pathways for the progression of diabetic nephropathy. In recent years, many researchers have been convinced that the inflammation pathways play central roles in the progression of diabetic nephropathy, and the identification of new inflammatory molecules may link to the development of new therapeutic strategies. Various molecules related to the inflammation pathways in diabetic nephropathy include transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules, Toll-like receptors, adipokines and nuclear receptors, which are candidates for the new molecular targets for the treatment of diabetic nephropathy. Understanding of these molecular pathways of inflammation would translate into the development of anti-inflammation therapeutic strategies." @default.
- W2020133142 created "2016-06-24" @default.
- W2020133142 creator A5007276836 @default.
- W2020133142 creator A5039655833 @default.
- W2020133142 date "2012-10-02" @default.
- W2020133142 modified "2023-10-13" @default.
- W2020133142 title "Inflammation and the pathogenesis of diabetic nephropathy" @default.
- W2020133142 cites W1484016032 @default.
- W2020133142 cites W1530509485 @default.
- W2020133142 cites W1564241462 @default.
- W2020133142 cites W1598235393 @default.
- W2020133142 cites W1813395665 @default.
- W2020133142 cites W1932654578 @default.
- W2020133142 cites W1964395052 @default.
- W2020133142 cites W1965923590 @default.
- W2020133142 cites W1967463529 @default.
- W2020133142 cites W1967839371 @default.
- W2020133142 cites W1973050206 @default.
- W2020133142 cites W1974384653 @default.
- W2020133142 cites W1976077502 @default.
- W2020133142 cites W1976124390 @default.
- W2020133142 cites W1980670415 @default.
- W2020133142 cites W1985446951 @default.
- W2020133142 cites W1986805128 @default.
- W2020133142 cites W1988943265 @default.
- W2020133142 cites W1990641914 @default.
- W2020133142 cites W1991083771 @default.
- W2020133142 cites W1992436810 @default.
- W2020133142 cites W1993193694 @default.
- W2020133142 cites W1996610877 @default.
- W2020133142 cites W1996854381 @default.
- W2020133142 cites W1997256303 @default.
- W2020133142 cites W1997676435 @default.
- W2020133142 cites W1997895757 @default.
- W2020133142 cites W1998378885 @default.
- W2020133142 cites W1999683656 @default.
- W2020133142 cites W2000254240 @default.
- W2020133142 cites W2000500184 @default.
- W2020133142 cites W2002670032 @default.
- W2020133142 cites W2003262346 @default.
- W2020133142 cites W2003370392 @default.
- W2020133142 cites W2003574534 @default.
- W2020133142 cites W2003582228 @default.
- W2020133142 cites W2004227877 @default.
- W2020133142 cites W2004479442 @default.
- W2020133142 cites W2006938377 @default.
- W2020133142 cites W2012049901 @default.
- W2020133142 cites W2012640720 @default.
- W2020133142 cites W2013361746 @default.
- W2020133142 cites W2016647872 @default.
- W2020133142 cites W2017959010 @default.
- W2020133142 cites W2018194092 @default.
- W2020133142 cites W2018227730 @default.
- W2020133142 cites W2018240571 @default.
- W2020133142 cites W2020289469 @default.
- W2020133142 cites W2022039209 @default.
- W2020133142 cites W2023320327 @default.
- W2020133142 cites W2024641784 @default.
- W2020133142 cites W2025798793 @default.
- W2020133142 cites W2026480246 @default.
- W2020133142 cites W2026659211 @default.
- W2020133142 cites W2028120895 @default.
- W2020133142 cites W2029818480 @default.
- W2020133142 cites W2030082547 @default.
- W2020133142 cites W2030936432 @default.
- W2020133142 cites W2032524530 @default.
- W2020133142 cites W2032874265 @default.
- W2020133142 cites W2032997554 @default.
- W2020133142 cites W2035793960 @default.
- W2020133142 cites W2039629336 @default.
- W2020133142 cites W2041531589 @default.
- W2020133142 cites W2042646534 @default.
- W2020133142 cites W2049735903 @default.
- W2020133142 cites W2051210500 @default.
- W2020133142 cites W2052146878 @default.
- W2020133142 cites W2054897365 @default.
- W2020133142 cites W2056137383 @default.
- W2020133142 cites W2057087278 @default.
- W2020133142 cites W2057516164 @default.
- W2020133142 cites W2062654696 @default.
- W2020133142 cites W2063643029 @default.
- W2020133142 cites W2065860064 @default.
- W2020133142 cites W2068809230 @default.
- W2020133142 cites W2069775587 @default.
- W2020133142 cites W2073387253 @default.
- W2020133142 cites W2074533395 @default.
- W2020133142 cites W2076451420 @default.
- W2020133142 cites W2079704762 @default.
- W2020133142 cites W2079785479 @default.
- W2020133142 cites W2079932751 @default.
- W2020133142 cites W2080207036 @default.
- W2020133142 cites W2081111107 @default.
- W2020133142 cites W2084279851 @default.
- W2020133142 cites W2085133650 @default.
- W2020133142 cites W2085211563 @default.
- W2020133142 cites W2085611491 @default.
- W2020133142 cites W2086495547 @default.
- W2020133142 cites W2086978939 @default.