FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020133275> ?p ?o ?g. }

• W2020133275 endingPage "794" @default.
• W2020133275 startingPage "788" @default.
• W2020133275 abstract "1. The ability of various C-C chemokines to elicit tissue eosinophil infiltration following intradermal injection or peripheral blood eosinophilia following intravenous injection were compared in the Brown-Norway rat. 2. Eotaxin (0.1 - 3 microg site-1) of human and murine origin produced equivalent, dose-dependent increases in eosinophil peroxidase activity in rat dermis 4 h post-injection. 3. Human eotaxin-2 was equipotent with human eotaxin in terms of dermal eosinophil recruitment. Other human CCR3 agonists, such as MCP-3, RANTES and MCP-4 failed to increase dermal eosinophil peroxidase activity at doses up to 1 microg site-1 whereas the latter did produce a small effect at 3 microg site-1. 4. Consistent with observations in vivo, human eotaxin displaced [125I]-eotaxin from rat spleen membranes more potently (IC50=2 nM) than did MCP-4 (IC50=500 nM). RANTES did not compete with the radiolabelled chemokine at concentrations up to 1 microM. 5. Human eotaxin (5 microg) administered intravenously increased circulating eosinophils approximately 3 fold whereas MCP-4 (5 microg i.v.) increased circulating monocytes approximately 3 fold without affecting eosinophil numbers. 6. Dexamethasone pretreatment inhibited eotaxin-induced dermal eosinophil influx only at a steroid dose (0.1 mg kg-1, s.c.) which significantly reduced circulating eosinophil numbers. The steroid also reduced eosinophilia in peripheral blood resulting from systemic eotaxin administration (5 microg, i.v.). 7. These data suggest differences in rat CCR3 relative to other species as surmised from a distinctive rank order of chemokine potency. In addition to its chemotactic effects eotaxin, but not MCP-4, promotes eosinophil recruitment into the circulation. One of the mechanisms by which glucocorticoids, such as dexamethasone, acutely inhibits eotaxin-induced dermal eosinophil influx is to diminish the circulating numbers of these cells available for tissue recruitment." @default.
• W2020133275 created "2016-06-24" @default.
• W2020133275 creator A5002322952 @default.
• W2020133275 creator A5010879918 @default.
• W2020133275 creator A5027092636 @default.
• W2020133275 creator A5043901604 @default.
• W2020133275 creator A5050386981 @default.
• W2020133275 date "1999-10-01" @default.
• W2020133275 modified "2023-10-18" @default.
• W2020133275 title "Characterization of chemokine CCR3 agonist-mediated eosinophil recruitment in the Brown-Norway rat" @default.
• W2020133275 cites W1554360333 @default.
• W2020133275 cites W1563378710 @default.
• W2020133275 cites W1604941563 @default.
• W2020133275 cites W1671219548 @default.
• W2020133275 cites W180810881 @default.
• W2020133275 cites W1858089130 @default.
• W2020133275 cites W1969551356 @default.
• W2020133275 cites W1981049346 @default.
• W2020133275 cites W1981773032 @default.
• W2020133275 cites W1982286823 @default.
• W2020133275 cites W1989680178 @default.
• W2020133275 cites W1992987846 @default.
• W2020133275 cites W1995347243 @default.
• W2020133275 cites W2023520187 @default.
• W2020133275 cites W2033043906 @default.
• W2020133275 cites W2034146535 @default.
• W2020133275 cites W2037663265 @default.
• W2020133275 cites W2046292402 @default.
• W2020133275 cites W2050252115 @default.
• W2020133275 cites W2052260815 @default.
• W2020133275 cites W2060088029 @default.
• W2020133275 cites W2084784729 @default.
• W2020133275 cites W2094618395 @default.
• W2020133275 cites W2095784197 @default.
• W2020133275 cites W2102675454 @default.
• W2020133275 cites W2113736505 @default.
• W2020133275 cites W2135474288 @default.
• W2020133275 cites W2137664573 @default.
• W2020133275 cites W2149640749 @default.
• W2020133275 cites W2312870247 @default.
• W2020133275 cites W2336300624 @default.
• W2020133275 cites W2430626426 @default.
• W2020133275 cites W40765902 @default.
• W2020133275 cites W4254446533 @default.
• W2020133275 doi "https://doi.org/10.1038/sj.bjp.0702835" @default.
• W2020133275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1571676" @default.
• W2020133275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10516663" @default.
• W2020133275 hasPublicationYear "1999" @default.
• W2020133275 type Work @default.
• W2020133275 sameAs 2020133275 @default.
• W2020133275 citedByCount "6" @default.
• W2020133275 crossrefType "journal-article" @default.
• W2020133275 hasAuthorship W2020133275A5002322952 @default.
• W2020133275 hasAuthorship W2020133275A5010879918 @default.
• W2020133275 hasAuthorship W2020133275A5027092636 @default.
• W2020133275 hasAuthorship W2020133275A5043901604 @default.
• W2020133275 hasAuthorship W2020133275A5050386981 @default.
• W2020133275 hasBestOaLocation W20201332751 @default.
• W2020133275 hasConcept C126322002 @default.
• W2020133275 hasConcept C12823836 @default.
• W2020133275 hasConcept C128879288 @default.
• W2020133275 hasConcept C13373296 @default.
• W2020133275 hasConcept C134018914 @default.
• W2020133275 hasConcept C1423137 @default.
• W2020133275 hasConcept C185592680 @default.
• W2020133275 hasConcept C203014093 @default.
• W2020133275 hasConcept C2776042228 @default.
• W2020133275 hasConcept C2776914184 @default.
• W2020133275 hasConcept C2777037409 @default.
• W2020133275 hasConcept C2777129736 @default.
• W2020133275 hasConcept C2777716647 @default.
• W2020133275 hasConcept C2778081958 @default.
• W2020133275 hasConcept C71924100 @default.
• W2020133275 hasConcept C86803240 @default.
• W2020133275 hasConcept C98274493 @default.
• W2020133275 hasConceptScore W2020133275C126322002 @default.
• W2020133275 hasConceptScore W2020133275C12823836 @default.
• W2020133275 hasConceptScore W2020133275C128879288 @default.
• W2020133275 hasConceptScore W2020133275C13373296 @default.
• W2020133275 hasConceptScore W2020133275C134018914 @default.
• W2020133275 hasConceptScore W2020133275C1423137 @default.
• W2020133275 hasConceptScore W2020133275C185592680 @default.
• W2020133275 hasConceptScore W2020133275C203014093 @default.
• W2020133275 hasConceptScore W2020133275C2776042228 @default.
• W2020133275 hasConceptScore W2020133275C2776914184 @default.
• W2020133275 hasConceptScore W2020133275C2777037409 @default.
• W2020133275 hasConceptScore W2020133275C2777129736 @default.
• W2020133275 hasConceptScore W2020133275C2777716647 @default.
• W2020133275 hasConceptScore W2020133275C2778081958 @default.
• W2020133275 hasConceptScore W2020133275C71924100 @default.
• W2020133275 hasConceptScore W2020133275C86803240 @default.
• W2020133275 hasConceptScore W2020133275C98274493 @default.
• W2020133275 hasIssue "3" @default.
• W2020133275 hasLocation W20201332751 @default.
• W2020133275 hasLocation W20201332752 @default.
• W2020133275 hasLocation W20201332753 @default.
• W2020133275 hasLocation W20201332754 @default.
• W2020133275 hasOpenAccess W2020133275 @default.

• next