FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020134809> ?p ?o ?g. }

• W2020134809 endingPage "382" @default.
• W2020134809 startingPage "367" @default.
• W2020134809 abstract "1. In agreement with the report by Féray & Garay (1986) it is shown that Mg2+ leaves human red cells mainly by a saturable pathway at a maximal rate of some 200 mumol 1(-1) cells h(-1) only if the medium contains Na+.Mg2+0.5 (i.e. the free Mg2+ concentration for half-maximal rate) at the internal membrane surface is 1.3 mM and the dissociation constant for Na+, KNa, at the external surface is 16-17 mM. Mg2+ shows co-operative behaviour. The Na+o-stimulated Mg2+ outflow is sensitive to millimolar amiloride concentrations. Implication of the Na+ or Ca+ pump can be ruled out. 2. Na+i is inhibitory by simple competition with Na+o. The affinity for Na+ inside is the same as outside. There is no detectable competition between Na+i and Mg2+i. 3. At approximately 1 mM-[Mg2+]i the outward Mg2+ movement stimulated by Na+o still proceeds when [Mg2+]o is increased up to 20 mM. Thus the Mg2+ movement is uphill and the apparent Mg2+0.5 at the external surface is larger than 20 mM. 4. Reversing the Na+ gradient (making [Na+]i greater than [Na+]o) does not elicit an inward Mg2+ movement, even if [Mg2+]o is simultaneously made larger than [Mg2+]i. 5. The Na+o-dependent Mg2+ outflow ceases nearly completely (falling to 5% of the control) in metabolically depleted cells. 6. The behaviour observed is compatible with the assumptions that (1) the system possesses distinct binding sites for Na+ and for Mg2+, (2) the ionophoric moiety is passively mobile when loaded with Na+, (3) the movement of the Na+ form is rate limiting, and (4) the Mg2+ form preferentially moves in the outward direction owing to an input of metabolic energy (ATP hydrolysis) and is immobile in starved cells. 7. Mg2+ may be required at a further site(s) not involved in the actual Mg2+ translocation but in the energy input. The simple kinetics suggesting translocation of one Na+ ion in exchange for one Mg2+ ion were found in selected cells of average maximum transport rate (Vmax) and may not hold for all cell specimens. 8. The conclusion is that the system is a Mg2+ extrusion pump driven by metabolic energy directly and not by the inward Na+ gradient, although net inward Na+ movement is necessary to bring the ionophoric part of the system back to the in-position. It appears that in intact cells the system operates far below saturation by Mg2+i and, by compensating for an inward leak of less than 5 mumol,1(-1) cells h(-1), sets the internal free Mg2+ concentration at about 0.5 of the equilibrium value." @default.
• W2020134809 created "2016-06-24" @default.
• W2020134809 creator A5014874393 @default.
• W2020134809 creator A5052199231 @default.
• W2020134809 date "1987-09-01" @default.
• W2020134809 modified "2023-09-26" @default.
• W2020134809 title "Some properties of a system for sodium-dependent outward movement of magnesium from metabolizing human red blood cells." @default.
• W2020134809 cites W1494139209 @default.
• W2020134809 cites W1539661565 @default.
• W2020134809 cites W1963574488 @default.
• W2020134809 cites W1972098739 @default.
• W2020134809 cites W1977444341 @default.
• W2020134809 cites W1988423854 @default.
• W2020134809 cites W2000017874 @default.
• W2020134809 cites W2010518771 @default.
• W2020134809 cites W2012111248 @default.
• W2020134809 cites W2025554401 @default.
• W2020134809 cites W2028378191 @default.
• W2020134809 cites W2030781430 @default.
• W2020134809 cites W2068497663 @default.
• W2020134809 cites W2077945373 @default.
• W2020134809 cites W2085187585 @default.
• W2020134809 cites W2162293702 @default.
• W2020134809 cites W2164964463 @default.
• W2020134809 cites W2166145769 @default.
• W2020134809 cites W2339138486 @default.
• W2020134809 cites W2398785151 @default.
• W2020134809 cites W4211074644 @default.
• W2020134809 doi "https://doi.org/10.1113/jphysiol.1987.sp016706" @default.
• W2020134809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1192186" @default.
• W2020134809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3443939" @default.
• W2020134809 hasPublicationYear "1987" @default.
• W2020134809 type Work @default.
• W2020134809 sameAs 2020134809 @default.
• W2020134809 citedByCount "53" @default.
• W2020134809 countsByYear W20201348092012 @default.
• W2020134809 countsByYear W20201348092022 @default.
• W2020134809 crossrefType "journal-article" @default.
• W2020134809 hasAuthorship W2020134809A5014874393 @default.
• W2020134809 hasAuthorship W2020134809A5052199231 @default.
• W2020134809 hasBestOaLocation W20201348092 @default.
• W2020134809 hasConcept C102931765 @default.
• W2020134809 hasConcept C12554922 @default.
• W2020134809 hasConcept C147789679 @default.
• W2020134809 hasConcept C170493617 @default.
• W2020134809 hasConcept C178790620 @default.
• W2020134809 hasConcept C185592680 @default.
• W2020134809 hasConcept C2779608910 @default.
• W2020134809 hasConcept C537181965 @default.
• W2020134809 hasConcept C543218039 @default.
• W2020134809 hasConcept C55493867 @default.
• W2020134809 hasConcept C74998103 @default.
• W2020134809 hasConcept C86803240 @default.
• W2020134809 hasConceptScore W2020134809C102931765 @default.
• W2020134809 hasConceptScore W2020134809C12554922 @default.
• W2020134809 hasConceptScore W2020134809C147789679 @default.
• W2020134809 hasConceptScore W2020134809C170493617 @default.
• W2020134809 hasConceptScore W2020134809C178790620 @default.
• W2020134809 hasConceptScore W2020134809C185592680 @default.
• W2020134809 hasConceptScore W2020134809C2779608910 @default.
• W2020134809 hasConceptScore W2020134809C537181965 @default.
• W2020134809 hasConceptScore W2020134809C543218039 @default.
• W2020134809 hasConceptScore W2020134809C55493867 @default.
• W2020134809 hasConceptScore W2020134809C74998103 @default.
• W2020134809 hasConceptScore W2020134809C86803240 @default.
• W2020134809 hasIssue "1" @default.
• W2020134809 hasLocation W20201348091 @default.
• W2020134809 hasLocation W20201348092 @default.
• W2020134809 hasLocation W20201348093 @default.
• W2020134809 hasOpenAccess W2020134809 @default.
• W2020134809 hasPrimaryLocation W20201348091 @default.
• W2020134809 hasRelatedWork W1547581450 @default.
• W2020134809 hasRelatedWork W2001944205 @default.
• W2020134809 hasRelatedWork W2007912210 @default.
• W2020134809 hasRelatedWork W2012670287 @default.
• W2020134809 hasRelatedWork W2057142141 @default.
• W2020134809 hasRelatedWork W2070839508 @default.
• W2020134809 hasRelatedWork W2088462076 @default.
• W2020134809 hasRelatedWork W2123369785 @default.
• W2020134809 hasRelatedWork W3023128169 @default.
• W2020134809 hasRelatedWork W4241787465 @default.
• W2020134809 hasVolume "390" @default.
• W2020134809 isParatext "false" @default.
• W2020134809 isRetracted "false" @default.
• W2020134809 magId "2020134809" @default.
• W2020134809 workType "article" @default.