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- W2020137259 abstract "Fisher ( F ) and Sprague Dawley ( SD ) rats were trained to press a lever on a fixed interval (FI) schedule of food reinforcement or to postpone electric footshock on an unsignaled, continuous avoidance schedule. F strain rats responded on the Fl schedule at a lower rate than the SD rats. Responding of F rats was increased by low doses (0.075–0.10 mg/kg, ip) of d -amphetamine that had no effect on SD rats. However, linear regression analysis of successive quartiles of FI responding indicated little difference between strains in terms of the rate-dependent effects of d -amphetamine (0.075–1.0 mg/kg, ip). In the continuous avoidance procedure, F strain rats had a baseline response rate that was almost twice that of SD rats. However, F strain rats were more sensitive than SD rats to the rate-increasing effects of d -amphetamine (0.1–1.0 mg/kg). Under both schedules of operant responding, SD rats appeared to be more sensitive than F rats to the effects of LSD (0.01-0.8 mg/kg, ip). Strain-related differences in sensitivity to the behavioral effects of d -amphetamine and LSD were not predicted from the observed differences in control baseline." @default.
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- W2020137259 date "1976-08-01" @default.
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- W2020137259 title "Comparison of the effects of d-amphetamine and lysergic acid diethylamide in two strains of rats having different behavioral baselines" @default.
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- W2020137259 doi "https://doi.org/10.1016/s0091-6773(76)90847-6" @default.
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