FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020137264> ?p ?o ?g. }

• W2020137264 abstract "Dozens of randomized controlled trials (RCTs) and meta-analyses have demonstrated the efficacy of repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) treatment, but there has not been a meta-analysis report which evaluates the efficacy and tolerability of rTMS used as an augmentative strategy for antidepressants in treatment-resistant depression (TRD) treatment. We thus conducted this meta-analysis, aimed at clarifying whether rTMS enhances the efficacy of TRD. We searched MEDLINE and Cochrane Central Register of Controlled Trials for RCTs for studying the efficacy of rTMS versus (vs) sham condition when combined with antidepressants in TRD treatment, and screened the references of the previous meta-analysis about the rTMS for MDD treatment. Response rates and NNT were chose as the primary outcomes, and remission rates, change from baseline of HAMD scores, dropouts were used as secondary outcomes. For dichotomous data, an intention-to-treat analysis principle was applied; for continuous data, we calculated the standard mean difference between groups with a random-effect model. Sensitivity analysis was done to explore the source of heterogeneity and the factors which potentially impact the efficacy. Seven RCTs were finally included in the meta-analysis. The total sample size was 279, with 171 in the rTMS group and 108 in the sham group. The pooled response and remission rate for the rTMS and sham group was 46.6% and 22.1%, respectively; the pooled odds ratio (OR) was 5.12 [95% confidence interval (CI) 2.11-12.45, z = 3.60, p = 0.0003, and the associated number needed to treat (NNT) was 3.4. rTMS group achieved a significant reduction of HAMD score than the sham group, the pooled SMD of change from baseline was 0.86 [95% confidence interval (CI) 0.57-1.15, z = 5.75, p < 0.00001]. Because of the small number of included RCTs, the preplanned sensitivity and subgroup analyses were finally abandoned. The dropouts in both groups were relatively low, indicating the high acceptability of rTMS. For TRD patients, augmentative rTMS after the failure of medications significantly increases the effect of antidepressants, and rTMS was a safe strategy with relatively low adverse events and low dropout rate, suggesting that augmentative rTMS is an effective intervention for TRD." @default.
• W2020137264 created "2016-06-24" @default.
• W2020137264 creator A5036852422 @default.
• W2020137264 creator A5059911480 @default.
• W2020137264 creator A5066716873 @default.
• W2020137264 creator A5086664284 @default.
• W2020137264 date "2014-11-30" @default.
• W2020137264 modified "2023-10-17" @default.
• W2020137264 title "Repetitive transcranial magnetic stimulation as an augmentative strategy for treatment-resistant depression, a meta-analysis of randomized, double-blind and sham-controlled study" @default.
• W2020137264 cites W1488490703 @default.
• W2020137264 cites W1515854428 @default.
• W2020137264 cites W1535428993 @default.
• W2020137264 cites W1752063994 @default.
• W2020137264 cites W1840814192 @default.
• W2020137264 cites W1971993531 @default.
• W2020137264 cites W1980475719 @default.
• W2020137264 cites W1980530587 @default.
• W2020137264 cites W1981005549 @default.
• W2020137264 cites W1997284631 @default.
• W2020137264 cites W1999286152 @default.
• W2020137264 cites W2002185073 @default.
• W2020137264 cites W2022244009 @default.
• W2020137264 cites W2024105269 @default.
• W2020137264 cites W2027751176 @default.
• W2020137264 cites W2030434698 @default.
• W2020137264 cites W2038883174 @default.
• W2020137264 cites W2047001332 @default.
• W2020137264 cites W2047084603 @default.
• W2020137264 cites W2047256315 @default.
• W2020137264 cites W2053371208 @default.
• W2020137264 cites W2054154385 @default.
• W2020137264 cites W2063194990 @default.
• W2020137264 cites W2070063667 @default.
• W2020137264 cites W2082494955 @default.
• W2020137264 cites W2090368299 @default.
• W2020137264 cites W2095140977 @default.
• W2020137264 cites W2096837838 @default.
• W2020137264 cites W2126930838 @default.
• W2020137264 cites W2127138731 @default.
• W2020137264 cites W2139218465 @default.
• W2020137264 cites W2140122849 @default.
• W2020137264 cites W2143805083 @default.
• W2020137264 cites W2149866856 @default.
• W2020137264 cites W2156092714 @default.
• W2020137264 cites W2164061367 @default.
• W2020137264 cites W2171771351 @default.
• W2020137264 cites W2291794699 @default.
• W2020137264 cites W3125307637 @default.
• W2020137264 cites W40250867 @default.
• W2020137264 cites W56753548 @default.
• W2020137264 doi "https://doi.org/10.1186/s12888-014-0342-4" @default.
• W2020137264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4264336" @default.
• W2020137264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25433539" @default.
• W2020137264 hasPublicationYear "2014" @default.
• W2020137264 type Work @default.
• W2020137264 sameAs 2020137264 @default.
• W2020137264 citedByCount "56" @default.
• W2020137264 countsByYear W20201372642015 @default.
• W2020137264 countsByYear W20201372642016 @default.
• W2020137264 countsByYear W20201372642017 @default.
• W2020137264 countsByYear W20201372642018 @default.
• W2020137264 countsByYear W20201372642019 @default.
• W2020137264 countsByYear W20201372642020 @default.
• W2020137264 countsByYear W20201372642021 @default.
• W2020137264 countsByYear W20201372642022 @default.
• W2020137264 countsByYear W20201372642023 @default.
• W2020137264 crossrefType "journal-article" @default.
• W2020137264 hasAuthorship W2020137264A5036852422 @default.
• W2020137264 hasAuthorship W2020137264A5059911480 @default.
• W2020137264 hasAuthorship W2020137264A5066716873 @default.
• W2020137264 hasAuthorship W2020137264A5086664284 @default.
• W2020137264 hasBestOaLocation W20201372641 @default.
• W2020137264 hasConcept C118552586 @default.
• W2020137264 hasConcept C126322002 @default.
• W2020137264 hasConcept C139719470 @default.
• W2020137264 hasConcept C156957248 @default.
• W2020137264 hasConcept C15744967 @default.
• W2020137264 hasConcept C162324750 @default.
• W2020137264 hasConcept C168563851 @default.
• W2020137264 hasConcept C197934379 @default.
• W2020137264 hasConcept C24998067 @default.
• W2020137264 hasConcept C2776867660 @default.
• W2020137264 hasConcept C2777342061 @default.
• W2020137264 hasConcept C2778375690 @default.
• W2020137264 hasConcept C2778581513 @default.
• W2020137264 hasConcept C2780051608 @default.
• W2020137264 hasConcept C2780733359 @default.
• W2020137264 hasConcept C28804328 @default.
• W2020137264 hasConcept C44249647 @default.
• W2020137264 hasConcept C71924100 @default.
• W2020137264 hasConcept C95190672 @default.
• W2020137264 hasConceptScore W2020137264C118552586 @default.
• W2020137264 hasConceptScore W2020137264C126322002 @default.
• W2020137264 hasConceptScore W2020137264C139719470 @default.
• W2020137264 hasConceptScore W2020137264C156957248 @default.
• W2020137264 hasConceptScore W2020137264C15744967 @default.
• W2020137264 hasConceptScore W2020137264C162324750 @default.
• W2020137264 hasConceptScore W2020137264C168563851 @default.
• W2020137264 hasConceptScore W2020137264C197934379 @default.
• W2020137264 hasConceptScore W2020137264C24998067 @default.

• next