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- W2020138304 abstract "Abstract The effects of amphotericin B (AmB) on four established animal cell lines were compared. measuring cell viability, inhibition of uridine incorporation into RNA, leakage of the enzyme lactate dehydrogenase, and leakage of RNA. In all assays, cell susceptibilities, in decreasing order, were: 3T3, L, BHK and HeLa. The cells, which were more sensitive, had significantly lower cholesterol:phospholipid ratios (c:p) than the less sensitive cells. Furthermore, 3T3 and L cell lines adapted to growth on higher levels of AmB had higher c:p molar ratios than did nonresistant cells. AmB binding to the cell was similar for all of the cell lines tested. These observations suggest a possible relationship between c:p ratios and sensitivity of cells to polyenes." @default.
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- W2020138304 title "Sensitivity to amphotericin B and the cholesterol: Phospholipid molar ratios of 3T3, L, BHK and HeLa cells" @default.
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- W2020138304 doi "https://doi.org/10.1016/0006-2952(77)90212-x" @default.
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