Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020138810> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2020138810 endingPage "742" @default.
- W2020138810 startingPage "739" @default.
- W2020138810 abstract "Autoantibodies arise when there is a breakdown in immunological tolerance. Autoantibodies to parietal cells and intrinsic factor are found in autoimmune atrophic gastritis (AAG) and are associated with elevated plasma gastrin. Endogenous gastrin autoantibodies have not been described to date. The aim of this study was to investigate the occurrence of autoantibodies to gastrin. Plasma from 50,000 patients, including more than 2000 with AAG, was tested. Gastrin was measured by radioimmunoassay (RIA) in whole plasma and the presence of autoantibody determined by using a control which omitted assay antibody. The quantity and affinity of gastrin autoantibodies was assessed. Three patients had autoantibodies to gastrin. All three had AAG and pernicious anaemia (PA). The antibodies were of low titre and relatively high affinity. Free circulating plasma gastrin levels were within the normal range, but total gastrin levels were elevated. This is the first description of autoantibodies to endogenous gastrin. The incidence of antibodies to gastrin is low, they are found in association with PA, and they may lead to falsely low measurements of plasma gastrin." @default.
- W2020138810 created "2016-06-24" @default.
- W2020138810 creator A5050852954 @default.
- W2020138810 date "1998-11-01" @default.
- W2020138810 modified "2023-09-23" @default.
- W2020138810 title "Autoantibodies to gastrin in patients with pernicious anaemia--a novel antibody" @default.
- W2020138810 doi "https://doi.org/10.1093/qjmed/91.11.739" @default.
- W2020138810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10024936" @default.
- W2020138810 hasPublicationYear "1998" @default.
- W2020138810 type Work @default.
- W2020138810 sameAs 2020138810 @default.
- W2020138810 citedByCount "2" @default.
- W2020138810 countsByYear W20201388102014 @default.
- W2020138810 crossrefType "journal-article" @default.
- W2020138810 hasAuthorship W2020138810A5050852954 @default.
- W2020138810 hasBestOaLocation W20201388101 @default.
- W2020138810 hasConcept C126322002 @default.
- W2020138810 hasConcept C134018914 @default.
- W2020138810 hasConcept C159654299 @default.
- W2020138810 hasConcept C163764329 @default.
- W2020138810 hasConcept C176685330 @default.
- W2020138810 hasConcept C203014093 @default.
- W2020138810 hasConcept C2776986829 @default.
- W2020138810 hasConcept C2777569460 @default.
- W2020138810 hasConcept C2778677798 @default.
- W2020138810 hasConcept C2779422922 @default.
- W2020138810 hasConcept C2780130043 @default.
- W2020138810 hasConcept C2780342937 @default.
- W2020138810 hasConcept C2910396959 @default.
- W2020138810 hasConcept C3017897077 @default.
- W2020138810 hasConcept C49039625 @default.
- W2020138810 hasConcept C71924100 @default.
- W2020138810 hasConceptScore W2020138810C126322002 @default.
- W2020138810 hasConceptScore W2020138810C134018914 @default.
- W2020138810 hasConceptScore W2020138810C159654299 @default.
- W2020138810 hasConceptScore W2020138810C163764329 @default.
- W2020138810 hasConceptScore W2020138810C176685330 @default.
- W2020138810 hasConceptScore W2020138810C203014093 @default.
- W2020138810 hasConceptScore W2020138810C2776986829 @default.
- W2020138810 hasConceptScore W2020138810C2777569460 @default.
- W2020138810 hasConceptScore W2020138810C2778677798 @default.
- W2020138810 hasConceptScore W2020138810C2779422922 @default.
- W2020138810 hasConceptScore W2020138810C2780130043 @default.
- W2020138810 hasConceptScore W2020138810C2780342937 @default.
- W2020138810 hasConceptScore W2020138810C2910396959 @default.
- W2020138810 hasConceptScore W2020138810C3017897077 @default.
- W2020138810 hasConceptScore W2020138810C49039625 @default.
- W2020138810 hasConceptScore W2020138810C71924100 @default.
- W2020138810 hasIssue "11" @default.
- W2020138810 hasLocation W20201388101 @default.
- W2020138810 hasLocation W20201388102 @default.
- W2020138810 hasOpenAccess W2020138810 @default.
- W2020138810 hasPrimaryLocation W20201388101 @default.
- W2020138810 hasRelatedWork W1444244449 @default.
- W2020138810 hasRelatedWork W1854118839 @default.
- W2020138810 hasRelatedWork W1992195062 @default.
- W2020138810 hasRelatedWork W2020138810 @default.
- W2020138810 hasRelatedWork W2043594903 @default.
- W2020138810 hasRelatedWork W2054626505 @default.
- W2020138810 hasRelatedWork W2085097890 @default.
- W2020138810 hasRelatedWork W2417312601 @default.
- W2020138810 hasRelatedWork W54355983 @default.
- W2020138810 hasRelatedWork W2384280892 @default.
- W2020138810 hasVolume "91" @default.
- W2020138810 isParatext "false" @default.
- W2020138810 isRetracted "false" @default.
- W2020138810 magId "2020138810" @default.
- W2020138810 workType "article" @default.