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• W2020140244 abstract "Radioactive sugar-nucleotides reacted with the microsomal fractions of rat and rabbit liver to form glycoproteins with endogenous acceptors. Triton X-100 caused 2- to 3-fold enhancement of incorporation, but the transfer enzyme system lost activity very rapidly under such conditions. Higher concentrations of sugar-nucleotides somewhat protected the enzymes. The transfer of hexosamine-N-acetyl from UDP-hexosamine-NAc was noncompetitively inhibited by UDP and UMP. Cyclic UMP, uridine, ADP, and AMP had no significant effect. The incorporation of mannose from GDP-mannose was inhibited by GDP, but UMP and UDP had only very slight inhibitory action. Snake venom phosphodiesterase also caused marked inhibition under conditions where it hydrolized only a fraction of UDP-hexosamine-NAc. Two products were observed in the reactions with UDP-galactose, UDP-hexosamine-NAc, and GDP-mannose; one was very labile to acid hydrolysis and could be extracted with lipid solvents, while the other was protein-bound sugar. The incorporation of hexosamine-NAc into the lipid was initially rapid then reached a plateau after about 10 min of reaction. The incorporation into protein was slower initially but proceeded longer at a steady rate. When microsomal fractions labeled previously with hexosamine-NAc-14C were treated with UMP or UDP, the radioactivity of the sugar-lipid decreased rather rapidly. Phosphodiesterase had a similar action. In a pulse-chase experiment the radioactivity of the sugar-lipid decreased, as expected from a precursor of the protein-bound sugar, and the activity of the protein increased concomitantly. The incorporation of UDP-3H and UMP-3H into UDP-glucosamine-NAc was also measured. Under the conditions of the tests only a minute amount of 3H could be detected in UDP-glucosamine-NAc." @default.
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• W2020140244 date "1970-05-01" @default.
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• W2020140244 title "Incorporation of carbohydrates into endogenous acceptors of liver microsomal fractions" @default.
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• W2020140244 doi "https://doi.org/10.1016/0003-9861(70)90292-4" @default.
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