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- W2020140537 abstract "Imiquimod and resiquimod represent Toll-like receptor (TLR) 7 and 8 agonists, which emerged as attractive candidates for tumor therapy. To elucidate immune cells, which mainly contribute to TLR7/8-mediated antitumoral activity, we investigated the impact of imiquimod and resiquimod on native human 6-sulfo LacNAc (slan) dendritic cells (DCs). We found that both TLR7/8 agonists significantly improve the release of various proinflammatory cytokines by slanDCs and promote their tumor-directed cytotoxic activity. Furthermore, resiquimod efficiently augmented the ability of slanDCs to stimulate T cells and natural killer cells. These results indicate that imiquimod and resiquimod trigger various immunostimulatory properties of slanDCs, which may contribute to their antitumor effects." @default.
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- W2020140537 date "2013-07-01" @default.
- W2020140537 modified "2023-10-07" @default.
- W2020140537 title "TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells" @default.
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- W2020140537 doi "https://doi.org/10.1016/j.canlet.2013.02.003" @default.
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