Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020141502> ?p ?o ?g. }
- W2020141502 endingPage "71" @default.
- W2020141502 startingPage "61" @default.
- W2020141502 abstract "The usefulness of sugar surfactants as solubilizing agents was assessed and compared to commercial polyoxyethylene-based surfactants. The sugar surfactants examined comprised of monosaccharides or disaccharides with alkyl chains ranging from C8 to C12. Each surfactant was investigated with respect to solubilization capacity for felodipine and haemolytic activity. The haemolytic activity was determined using a static method in which surfactant solutions were added to fresh dog blood. The polyoxyethylene-based surfactants were found to be more suitable as solubilizing agents than the sugar surfactants due to better solubilization capacities combined with lower haemolytic activities. The sugar surfactants caused severe haemolysis below or at the critical micelle concentration, in contrast to the polyoxyethylene-based surfactants that are nonhaemolytic in this concentration range. The structure-related variations in haemolytic activity are probably due to variations in the surfactants partition coefficients for the distribution equilibrium between the aqueous phase and the cell membrane. Longer alkyl chains cause higher haemolytic activity, while larger saccharide groups lower the activity. The clear difference between sugar and polyoxyethylene surfactants, which are considerably less haemolytic, is due to a combination of low critical micelle concentrations and presumably low degrees of partitioning of the latter surfactants into the cell membranes." @default.
- W2020141502 created "2016-06-24" @default.
- W2020141502 creator A5013967903 @default.
- W2020141502 creator A5022978211 @default.
- W2020141502 creator A5049076658 @default.
- W2020141502 date "2003-02-01" @default.
- W2020141502 modified "2023-10-16" @default.
- W2020141502 title "The usefulness of sugar surfactants as solubilizing agents in parenteral formulations" @default.
- W2020141502 cites W1482341134 @default.
- W2020141502 cites W1486018397 @default.
- W2020141502 cites W1521625462 @default.
- W2020141502 cites W1581739687 @default.
- W2020141502 cites W1606251573 @default.
- W2020141502 cites W164496576 @default.
- W2020141502 cites W1959353171 @default.
- W2020141502 cites W1964633700 @default.
- W2020141502 cites W1965177590 @default.
- W2020141502 cites W1968400315 @default.
- W2020141502 cites W1969589548 @default.
- W2020141502 cites W1978118870 @default.
- W2020141502 cites W1983306302 @default.
- W2020141502 cites W1986015316 @default.
- W2020141502 cites W1990098432 @default.
- W2020141502 cites W2015784347 @default.
- W2020141502 cites W2017434735 @default.
- W2020141502 cites W2021558316 @default.
- W2020141502 cites W2021562517 @default.
- W2020141502 cites W2022272402 @default.
- W2020141502 cites W2025659048 @default.
- W2020141502 cites W2026957936 @default.
- W2020141502 cites W2034284481 @default.
- W2020141502 cites W2037221671 @default.
- W2020141502 cites W2040128886 @default.
- W2020141502 cites W2042885165 @default.
- W2020141502 cites W2044469431 @default.
- W2020141502 cites W2046885861 @default.
- W2020141502 cites W2066488905 @default.
- W2020141502 cites W2071134705 @default.
- W2020141502 cites W2071832789 @default.
- W2020141502 cites W2072032876 @default.
- W2020141502 cites W2076190184 @default.
- W2020141502 cites W2080772430 @default.
- W2020141502 cites W2088531830 @default.
- W2020141502 cites W2093539459 @default.
- W2020141502 cites W2110814172 @default.
- W2020141502 cites W2121057924 @default.
- W2020141502 cites W2122578501 @default.
- W2020141502 cites W2159980121 @default.
- W2020141502 cites W2321798949 @default.
- W2020141502 cites W2491892675 @default.
- W2020141502 cites W2512708706 @default.
- W2020141502 doi "https://doi.org/10.1016/s0378-5173(02)00599-9" @default.
- W2020141502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12550781" @default.
- W2020141502 hasPublicationYear "2003" @default.
- W2020141502 type Work @default.
- W2020141502 sameAs 2020141502 @default.
- W2020141502 citedByCount "73" @default.
- W2020141502 countsByYear W20201415022012 @default.
- W2020141502 countsByYear W20201415022013 @default.
- W2020141502 countsByYear W20201415022014 @default.
- W2020141502 countsByYear W20201415022015 @default.
- W2020141502 countsByYear W20201415022016 @default.
- W2020141502 countsByYear W20201415022017 @default.
- W2020141502 countsByYear W20201415022018 @default.
- W2020141502 countsByYear W20201415022019 @default.
- W2020141502 countsByYear W20201415022020 @default.
- W2020141502 countsByYear W20201415022021 @default.
- W2020141502 countsByYear W20201415022022 @default.
- W2020141502 countsByYear W20201415022023 @default.
- W2020141502 crossrefType "journal-article" @default.
- W2020141502 hasAuthorship W2020141502A5013967903 @default.
- W2020141502 hasAuthorship W2020141502A5022978211 @default.
- W2020141502 hasAuthorship W2020141502A5049076658 @default.
- W2020141502 hasConcept C11268172 @default.
- W2020141502 hasConcept C178790620 @default.
- W2020141502 hasConcept C184651966 @default.
- W2020141502 hasConcept C185592680 @default.
- W2020141502 hasConcept C192552737 @default.
- W2020141502 hasConcept C203014093 @default.
- W2020141502 hasConcept C2777108408 @default.
- W2020141502 hasConcept C2780263894 @default.
- W2020141502 hasConcept C2910801743 @default.
- W2020141502 hasConcept C41625074 @default.
- W2020141502 hasConcept C43617362 @default.
- W2020141502 hasConcept C55493867 @default.
- W2020141502 hasConcept C58226133 @default.
- W2020141502 hasConcept C64237528 @default.
- W2020141502 hasConcept C86803240 @default.
- W2020141502 hasConceptScore W2020141502C11268172 @default.
- W2020141502 hasConceptScore W2020141502C178790620 @default.
- W2020141502 hasConceptScore W2020141502C184651966 @default.
- W2020141502 hasConceptScore W2020141502C185592680 @default.
- W2020141502 hasConceptScore W2020141502C192552737 @default.
- W2020141502 hasConceptScore W2020141502C203014093 @default.
- W2020141502 hasConceptScore W2020141502C2777108408 @default.
- W2020141502 hasConceptScore W2020141502C2780263894 @default.
- W2020141502 hasConceptScore W2020141502C2910801743 @default.
- W2020141502 hasConceptScore W2020141502C41625074 @default.