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• W2020142113 abstract "The extracellular matrix plays important roles in embryogenesis. The integrin family of adhesion receptors may mediate critical cellular interactions with the extracellular matrix during development. In this study, we elucidated the developmental spatial and temporal expression pattern of the α2β1 integrin heterodimer, a cell surface receptor for collagens and laminin. We generated reagents for studying the α2β1 integrin and examined the developmental expression of the integrin in postimplantation mice. A partial length murine α2 cDNA was isolated and the protein encoding region was found to be 82% homologous to that of the human α2 cDNA. A synthetic peptide corresponding to the carboxy-terminus of murine α2 was used to generate α2-specific antiserum. The antiserum and riboprobes derived from both the α2 cDNA and the previously characterized murine β1 subunit cDNA were used to determine the spatiotemporal expression of the α2 subunit by immunocytochemistry and of the α2 and β1 mRNAs by in situ hybridization. Both approaches gave concordant results. Expression of the α2 integrin subunit was observed in both the maternal and embryonic components of the placenta, namely the perivascular and basal zone decidual cells and decidual cells and spongiotrophoblasts at the maternal/embryonic junction. Expression was also observed in cells actively producing and remodeling the extracellular matrix in the maternal uterus and in the developing gut, lens, cartilage, bone, and tooth of the embryo. Generally, expression of the α2 integrin subunit was found in cells entering their later stages of differentiation such as in chondrocytes as they became hypertrophic, ameloblasts and odontoblasts as they became columnar and began to secrete the matrix of the tooth, endothelial cells after they formed tubules, in the lens just prior to and during lens fiber production, and in the collecting ducts of the kidney only after full gestation. Throughout embryogenesis, β1 mRNA was widely distributed and present in cell types expressing α2 mRNA and protein. The developmental expression pattern of the α2β1 integrin suggests roles for the integrin in placental development and matrix assembly and remodeling. © 1994 Wiley-Liss, Inc." @default.
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• W2020142113 date "1994-04-01" @default.
• W2020142113 modified "2023-10-18" @default.
• W2020142113 title "Complex patterns of expression suggest extensive roles for the α2β1 integrin in murine development" @default.
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• W2020142113 doi "https://doi.org/10.1002/aja.1001990405" @default.
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