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- W2020144872 abstract "The protein hyper-secreting filamentous fungi impact their surrounding environments by secreting cellulases and digesting plant cell wall via microbe–plant interspecies interaction. This process is of paramount importance in biofuel production from the renewable lignocellulosic biomass, because cellulase production is the key factor in cost determination. Despite the importance of protein secretion, p24 protein, a key factor in eukaryotic protein maturation and secretion, was never investigated in filamentous fungi. The erp genes encoding p24γ homologues were identified in Trichoderma reesei and Penicillium decumbens. The roles of Erp and their participated cellular pathways were investigated via disruption of erp, revealing significant differences: sporulation was hampered in T. reesei Δerp but not in P. decumbens Δerp; in both species Erp maintains membrane integrity; Erp is likely involved in hyphae polarity maintenance in T. reesei. Protein- and transcription-level investigations of Erp participation in cellulase production revealed distinct regulatory mechanisms. In T. reesei, cellulase encoding genes were repressed under secretion stress. In contrast, activation of the same genes under the same stress was identified in P. decumbens. These observations revealed a novel cellulase gene regulation mechanism, clearly suggested the different physiological roles of Erp, and further demonstrated the different physiology of T. reesei and P. decumbens, despite above 75% sequence identity between the proteins and the close evolutionary relationship between the two species." @default.
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- W2020144872 date "2013-12-01" @default.
- W2020144872 modified "2023-09-25" @default.
- W2020144872 title "Functional diversity of the p24γ homologue Erp reveals physiological differences between two filamentous fungi" @default.
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- W2020144872 doi "https://doi.org/10.1016/j.fgb.2013.08.017" @default.
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