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- W2020147114 abstract "Abstract Mantle cell lymphoma (MCL) is a rare and aggressive form of non-Hodgkin’s lymphoma that generally affects older individuals and continues to have one of the worst outcomes of all the lymphomas. Over the last decade, there has been a widespread adoption of cytarabine-based therapy in younger patients, and the incorporation of rituximab into chemotherapeutic regimens has become an evidence-based standard of care. However MCL remains a largely incurable disease, and following relapse, it can be a challenge to manage. Although it is possible to define prognosis reliably, there are, as yet, no clear diagnostic or response-adjusted parameters that can help to guide therapeutic decisions. However, there are a number of highly active targeted therapies that are moving into the clinic that are set to transform the therapeutic paradigm for this disease in the very near future. This review will explore the molecular pathogenesis of MCL and the current and evolving therapeutic strategies for this disease." @default.
- W2020147114 created "2016-06-24" @default.
- W2020147114 creator A5059022907 @default.
- W2020147114 creator A5059097260 @default.
- W2020147114 date "2015-01-01" @default.
- W2020147114 modified "2023-10-10" @default.
- W2020147114 title "Mantle cell lymphoma: evolving management strategies" @default.
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- W2020147114 doi "https://doi.org/10.1182/blood-2014-05-521898" @default.
- W2020147114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25499451" @default.
- W2020147114 hasPublicationYear "2015" @default.
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