FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020147681> ?p ?o ?g. }

• W2020147681 endingPage "250" @default.
• W2020147681 startingPage "241" @default.
• W2020147681 abstract "Background Nucleoside reverse transcriptase inhibitors (NRTIs) disrupt neuronal mitochondrial DNA synthesis, resulting in antiretroviral toxic neuropathy (ATN). Acetyl‐ l ‐carnitine (ALCAR) enhances neurotrophic support of sensory neurones, potentially providing symptom relief and nerve regeneration. Objective The objective of the study was to assess the safety and efficacy compared to placebo of intramuscular ALCAR in HIV‐positive patients with symptomatic distal symmetrical polyneuropathy. Methods Ninety patients were enrolled and randomized to receive ALCAR [500 mg twice a day (bid); n =43] or placebo ( n =47) intramuscularly twice daily for 14 days followed by 42 days of oral ALCAR 1000 mg bid. Assessment of pain was obtained using the Visual Analogue Scale (VAS), Total Symptom Score (TSS), Clinical Global Impression of Change, McGill Pain Questionnaire (MPQ), and the need for rescue analgesics. Results There was no statistically significant difference in changes in VAS over 14 days between groups for the intent‐to‐treat (ITT) population, but for the efficacy‐evaluable (EE) population ALCAR treatment produced a significantly greater reduction in pain compared with placebo ( P= 0.022). The proportion of patients with an improvement in TSS over 14 days was greater in the ALCAR group compared with the placebo group, but the differences were not statistically significant. During the open‐label phase, patients experienced an improvement in pain, as measured by the VAS, TSS and McGill Pain Questionnaire. Conclusion ALCAR, administered twice a day intramuscularly to HIV‐1‐infected patients with symptomatic ATN, significantly reduced weekly mean pain ratings on the VAS compared with placebo. Treatment with oral ALCAR improved symptoms for the patient group as a whole. Intramuscular and oral ALCAR was generally safe and well tolerated." @default.
• W2020147681 created "2016-06-24" @default.
• W2020147681 creator A5047374087 @default.
• W2020147681 creator A5072983043 @default.
• W2020147681 date "2007-04-24" @default.
• W2020147681 modified "2023-10-10" @default.
• W2020147681 title "A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl l-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection" @default.
• W2020147681 cites W1593899725 @default.
• W2020147681 cites W175251169 @default.
• W2020147681 cites W1978902758 @default.
• W2020147681 cites W1980890985 @default.
• W2020147681 cites W1996010873 @default.
• W2020147681 cites W1996753093 @default.
• W2020147681 cites W2001172623 @default.
• W2020147681 cites W2004874366 @default.
• W2020147681 cites W2014898575 @default.
• W2020147681 cites W2023592074 @default.
• W2020147681 cites W2029903095 @default.
• W2020147681 cites W2034760164 @default.
• W2020147681 cites W2039824535 @default.
• W2020147681 cites W2042067248 @default.
• W2020147681 cites W2053921484 @default.
• W2020147681 cites W2058345910 @default.
• W2020147681 cites W2060667176 @default.
• W2020147681 cites W2082466535 @default.
• W2020147681 cites W2084890679 @default.
• W2020147681 cites W2086168106 @default.
• W2020147681 cites W2093736201 @default.
• W2020147681 cites W2096722752 @default.
• W2020147681 cites W2113241465 @default.
• W2020147681 cites W2127591567 @default.
• W2020147681 cites W2140969998 @default.
• W2020147681 cites W2144996203 @default.
• W2020147681 doi "https://doi.org/10.1111/j.1468-1293.2007.00467.x" @default.
• W2020147681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17461852" @default.
• W2020147681 hasPublicationYear "2007" @default.
• W2020147681 type Work @default.
• W2020147681 sameAs 2020147681 @default.
• W2020147681 citedByCount "83" @default.
• W2020147681 countsByYear W20201476812012 @default.
• W2020147681 countsByYear W20201476812013 @default.
• W2020147681 countsByYear W20201476812014 @default.
• W2020147681 countsByYear W20201476812015 @default.
• W2020147681 countsByYear W20201476812016 @default.
• W2020147681 countsByYear W20201476812017 @default.
• W2020147681 countsByYear W20201476812018 @default.
• W2020147681 countsByYear W20201476812019 @default.
• W2020147681 countsByYear W20201476812020 @default.
• W2020147681 countsByYear W20201476812021 @default.
• W2020147681 countsByYear W20201476812022 @default.
• W2020147681 countsByYear W20201476812023 @default.
• W2020147681 crossrefType "journal-article" @default.
• W2020147681 hasAuthorship W2020147681A5047374087 @default.
• W2020147681 hasAuthorship W2020147681A5072983043 @default.
• W2020147681 hasBestOaLocation W20201476811 @default.
• W2020147681 hasConcept C126322002 @default.
• W2020147681 hasConcept C141071460 @default.
• W2020147681 hasConcept C14184104 @default.
• W2020147681 hasConcept C142724271 @default.
• W2020147681 hasConcept C204787440 @default.
• W2020147681 hasConcept C27081682 @default.
• W2020147681 hasConcept C2776432500 @default.
• W2020147681 hasConcept C2777107010 @default.
• W2020147681 hasConcept C2908647359 @default.
• W2020147681 hasConcept C42219234 @default.
• W2020147681 hasConcept C71924100 @default.
• W2020147681 hasConcept C99454951 @default.
• W2020147681 hasConceptScore W2020147681C126322002 @default.
• W2020147681 hasConceptScore W2020147681C141071460 @default.
• W2020147681 hasConceptScore W2020147681C14184104 @default.
• W2020147681 hasConceptScore W2020147681C142724271 @default.
• W2020147681 hasConceptScore W2020147681C204787440 @default.
• W2020147681 hasConceptScore W2020147681C27081682 @default.
• W2020147681 hasConceptScore W2020147681C2776432500 @default.
• W2020147681 hasConceptScore W2020147681C2777107010 @default.
• W2020147681 hasConceptScore W2020147681C2908647359 @default.
• W2020147681 hasConceptScore W2020147681C42219234 @default.
• W2020147681 hasConceptScore W2020147681C71924100 @default.
• W2020147681 hasConceptScore W2020147681C99454951 @default.
• W2020147681 hasIssue "4" @default.
• W2020147681 hasLocation W20201476811 @default.
• W2020147681 hasLocation W20201476812 @default.
• W2020147681 hasOpenAccess W2020147681 @default.
• W2020147681 hasPrimaryLocation W20201476811 @default.
• W2020147681 hasRelatedWork W1987967340 @default.
• W2020147681 hasRelatedWork W202490408 @default.
• W2020147681 hasRelatedWork W2025543467 @default.
• W2020147681 hasRelatedWork W2055207357 @default.
• W2020147681 hasRelatedWork W2146780921 @default.
• W2020147681 hasRelatedWork W2157509660 @default.
• W2020147681 hasRelatedWork W2911862372 @default.
• W2020147681 hasRelatedWork W2993948777 @default.
• W2020147681 hasRelatedWork W4387168278 @default.
• W2020147681 hasRelatedWork W2773062433 @default.
• W2020147681 hasVolume "8" @default.
• W2020147681 isParatext "false" @default.
• W2020147681 isRetracted "false" @default.
• W2020147681 magId "2020147681" @default.

• next