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- W2020149013 abstract "Abstract The effect of ADP-induced platelet aggregation upon blood flow, O 2 -consumption, and performance was investigated in isolated and autoperfused working canine gastrocnemius muscles. During steady state work a mean blood flow of 87.1 ± 33.7 ml × min −1 × 100 g −1 and a mean O 2 -consumption of 7.89 ± 4.03 ml × min −1 × 100 g −1 was found. The average amplitude of muscle contraction was 10.4 ± 4.1 mm. Changes of these parameters due to the ADP-infusion were found to depend upon the number of platelets which remained in the muscles during infusion. On the other hand this so-called platelet loss was significantly correlated with the arterial platelet count. In animals with a low arterial platelet count (below 10 4 /mm 3 ) platelet loss did not exceed 2 × 10 9 cells × min −1 × 100 g −1 . Blood flow as well as venous O 2 -saturation increased during ADP-infusion. In an experiment with a high platelet loss (14.3 × 10 9 cells × min −1 × 100 g −1 ) according to a platelet count of 390 × 10 3 /mm 3 muscle contraction and O 2 -consumption were reduced to approximately 30% of their preinfusion values. These changes, however, only were present during the time of ADP-infusion. After its termination the muscles started to recover immediately reaching the control values within 5 min." @default.
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- W2020149013 title "Hemodynamic and functional consequences of intravascular platelet aggregation in skeletal muscle" @default.
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- W2020149013 doi "https://doi.org/10.1016/0026-2862(75)90067-9" @default.
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