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- W2020149558 abstract "A family of human phenol sulfotransferase genes has been suggested by the cloning of numerous cDNA isolates from different tissues. We have previously cloned and sequenced theSTMgene encoding the monoamine neurotransmitter-preferring sulfotransferase, M-PST, and a portion of theSTP1gene encoding the phenol-preferring isozyme, P-PST1 (BBRC205,1325–1332;Genomics18,440–443). Both genes were mapped to a small region on the short arm of chromosome 16 (BBRC205,482–489). Here we report on the sequencing and genomic organization of theSTP1andSTP2genes from a single cosmid clone obtained from chromosome 16p12.1-p11.2.STP1andSTP2are 95.9% identical at the amino acid sequence level, whereas theSTMgene is only 92.9% and 90.5% identical toSTP1andSTP2,respectively. Alignment of the genomic sequences indicated that all three genes have 7 coding exons and conserved intron-exon boundaries. These results facilitated the assignment of previously published cDNA isolates as “alleles” of the individualSTM, STP1,andSTP2loci on 16p, and provide to us a greater understanding of the complexity and roles of the phenol sulfotransferase gene family in the metabolism of endogenous and xenobiotic agents." @default.
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- W2020149558 date "1996-11-01" @default.
- W2020149558 modified "2023-10-14" @default.
- W2020149558 title "Genomic Organization and DNA Sequences of Two Human Phenol Sulfotransferase Genes (STP1andSTP2) on the Short Arm of Chromosome 16" @default.
- W2020149558 doi "https://doi.org/10.1006/bbrc.1996.1628" @default.
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