Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020154355> ?p ?o ?g. }
- W2020154355 endingPage "170" @default.
- W2020154355 startingPage "165" @default.
- W2020154355 abstract "Human monocytes, alveolar macrophages, and blood platelets were used in vitro to investigate the effects of nedocromil sodium on their IgE-dependent stimulation. The drug induced a significant inhibition of the IgE-mediated generation of cytotoxic mediators in both cell populations. This was evidenced by a strong inhibition of the killing of schistosome larvae and decreased free radical production, as demonstrated by chemiluminescence. Nedocromil sodium also produced a significant inhibition of lysosomal enzyme release and synthesis in alveolar macrophages. These effects reached a maximum between 10(-9) and 10(-7) mol/L nedocromil sodium. The 50% inhibition concentration was 10 times lower. The drug was also tested on IgE-activated rat peritoneal macrophages and blood platelets with similar results. Finally, nedocromil sodium was shown to inhibit the abnormal response to aspirin of platelets, both in vitro and ex vivo, from aspirin-sensitive asthma patients." @default.
- W2020154355 created "2016-06-24" @default.
- W2020154355 creator A5041690009 @default.
- W2020154355 creator A5044374733 @default.
- W2020154355 creator A5070027627 @default.
- W2020154355 creator A5082947000 @default.
- W2020154355 date "1993-07-01" @default.
- W2020154355 modified "2023-09-27" @default.
- W2020154355 title "Modulation by nedocromil sodium of immunologic and nonimmunologic activation of monocytes, macrophages, and platelets" @default.
- W2020154355 cites W1246983667 @default.
- W2020154355 cites W1998197974 @default.
- W2020154355 cites W2003364712 @default.
- W2020154355 cites W2022409957 @default.
- W2020154355 cites W2027880812 @default.
- W2020154355 cites W2046403513 @default.
- W2020154355 cites W2051466218 @default.
- W2020154355 cites W2059874731 @default.
- W2020154355 cites W2062959538 @default.
- W2020154355 cites W2070001148 @default.
- W2020154355 cites W2076912190 @default.
- W2020154355 cites W2078571876 @default.
- W2020154355 cites W2086864461 @default.
- W2020154355 cites W2087338724 @default.
- W2020154355 cites W2094113756 @default.
- W2020154355 cites W2110624429 @default.
- W2020154355 cites W2140152586 @default.
- W2020154355 cites W2140909629 @default.
- W2020154355 cites W2189350768 @default.
- W2020154355 cites W2255443923 @default.
- W2020154355 cites W2407970308 @default.
- W2020154355 doi "https://doi.org/10.1016/0091-6749(93)90100-t" @default.
- W2020154355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8393022" @default.
- W2020154355 hasPublicationYear "1993" @default.
- W2020154355 type Work @default.
- W2020154355 sameAs 2020154355 @default.
- W2020154355 citedByCount "12" @default.
- W2020154355 countsByYear W20201543552013 @default.
- W2020154355 countsByYear W20201543552014 @default.
- W2020154355 countsByYear W20201543552015 @default.
- W2020154355 crossrefType "journal-article" @default.
- W2020154355 hasAuthorship W2020154355A5041690009 @default.
- W2020154355 hasAuthorship W2020154355A5044374733 @default.
- W2020154355 hasAuthorship W2020154355A5070027627 @default.
- W2020154355 hasAuthorship W2020154355A5082947000 @default.
- W2020154355 hasConcept C126322002 @default.
- W2020154355 hasConcept C141105273 @default.
- W2020154355 hasConcept C142724271 @default.
- W2020154355 hasConcept C150903083 @default.
- W2020154355 hasConcept C159654299 @default.
- W2020154355 hasConcept C185592680 @default.
- W2020154355 hasConcept C202751555 @default.
- W2020154355 hasConcept C203014093 @default.
- W2020154355 hasConcept C204787440 @default.
- W2020154355 hasConcept C207001950 @default.
- W2020154355 hasConcept C27081682 @default.
- W2020154355 hasConcept C2776002719 @default.
- W2020154355 hasConcept C2776178081 @default.
- W2020154355 hasConcept C2777628954 @default.
- W2020154355 hasConcept C2777714996 @default.
- W2020154355 hasConcept C2781184567 @default.
- W2020154355 hasConcept C2910070530 @default.
- W2020154355 hasConcept C3018697912 @default.
- W2020154355 hasConcept C55493867 @default.
- W2020154355 hasConcept C71924100 @default.
- W2020154355 hasConcept C86803240 @default.
- W2020154355 hasConcept C89560881 @default.
- W2020154355 hasConcept C98274493 @default.
- W2020154355 hasConceptScore W2020154355C126322002 @default.
- W2020154355 hasConceptScore W2020154355C141105273 @default.
- W2020154355 hasConceptScore W2020154355C142724271 @default.
- W2020154355 hasConceptScore W2020154355C150903083 @default.
- W2020154355 hasConceptScore W2020154355C159654299 @default.
- W2020154355 hasConceptScore W2020154355C185592680 @default.
- W2020154355 hasConceptScore W2020154355C202751555 @default.
- W2020154355 hasConceptScore W2020154355C203014093 @default.
- W2020154355 hasConceptScore W2020154355C204787440 @default.
- W2020154355 hasConceptScore W2020154355C207001950 @default.
- W2020154355 hasConceptScore W2020154355C27081682 @default.
- W2020154355 hasConceptScore W2020154355C2776002719 @default.
- W2020154355 hasConceptScore W2020154355C2776178081 @default.
- W2020154355 hasConceptScore W2020154355C2777628954 @default.
- W2020154355 hasConceptScore W2020154355C2777714996 @default.
- W2020154355 hasConceptScore W2020154355C2781184567 @default.
- W2020154355 hasConceptScore W2020154355C2910070530 @default.
- W2020154355 hasConceptScore W2020154355C3018697912 @default.
- W2020154355 hasConceptScore W2020154355C55493867 @default.
- W2020154355 hasConceptScore W2020154355C71924100 @default.
- W2020154355 hasConceptScore W2020154355C86803240 @default.
- W2020154355 hasConceptScore W2020154355C89560881 @default.
- W2020154355 hasConceptScore W2020154355C98274493 @default.
- W2020154355 hasIssue "1" @default.
- W2020154355 hasLocation W20201543551 @default.
- W2020154355 hasLocation W20201543552 @default.
- W2020154355 hasOpenAccess W2020154355 @default.
- W2020154355 hasPrimaryLocation W20201543551 @default.
- W2020154355 hasRelatedWork W1574451752 @default.
- W2020154355 hasRelatedWork W1940255321 @default.
- W2020154355 hasRelatedWork W1989929097 @default.