FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020154489> ?p ?o ?g. }

• W2020154489 endingPage "547" @default.
• W2020154489 startingPage "540" @default.
• W2020154489 abstract "Interrelationships among induction of cytochrome P-450 (CYP) 1A1/2, decrease in connexin 32 (Cx32), and liver tumor-promoting activity by beta-naphthoflavone (BNF) in the promotion stage were examined in a 2-stage liver carcinogenesis model. A total of 20 male Fischer 344 rats were initiated with a single intraperitoneal injection of 150 mg/kg of diethylnitrosamine (DEN) or were given the saline vehicle alone. Starting 2 weeks later, they were fed a diet containing 2%, 1%, or 0% BNF for 6 weeks. All animals were subjected to a two-thirds partial hepatectomy at week 3 and were sacrificed at week 8. Absolute and relative liver weights were significantly increased in the DEN+BNF groups as compared to the DEN-alone group. Diffuse hepatocellular hypertrophy with cytoplasmic eosinophilia, sometimes accompanied by development of adenoma-like hepatic foci, was observed in the BNF-treated rats. Remarkable induction of cytochrome CYP 1A1/2 and significant increase in CYP 2E1 were noted in the DEN+BNF groups, and positive immunohistochemical staining for both was observed diffusely. The areas of Cx32-positive spots per hepatocyte in the centrilobular areas of livers of the BNF-treated rats were significantly decreased, but no changes were observed in periportal areas. The numbers and areas of foci positive for glutathione S-transferase placental form were increased in the BNF-treated groups. These results suggest that BNF is a liver tumor promoter that, unlike phenobarbital, does not induce CYP 2B1/2 isozymes, and there seems to be no direct relationship between CYP 1A1/2 induction and Cx32 reduction in BNF hepatocarcinogenesis." @default.
• W2020154489 created "2016-06-24" @default.
• W2020154489 creator A5002004328 @default.
• W2020154489 creator A5019798222 @default.
• W2020154489 creator A5041880211 @default.
• W2020154489 creator A5041911355 @default.
• W2020154489 creator A5064056142 @default.
• W2020154489 creator A5081837886 @default.
• W2020154489 creator A5082211958 @default.
• W2020154489 date "2000-07-01" @default.
• W2020154489 modified "2023-10-14" @default.
• W2020154489 title "Live Tumor-Promoting Effect of β-Naphthoflavone, a Strong CYP 1A1/2 Inducer, and the Relationship between CYP 1A1/2 Induction and Cx32 Decrease in Its Hepatocarcinogenesis in the Rat" @default.
• W2020154489 cites W1706505140 @default.
• W2020154489 cites W1803921312 @default.
• W2020154489 cites W1965830185 @default.
• W2020154489 cites W1979171525 @default.
• W2020154489 cites W1983185789 @default.
• W2020154489 cites W2048573905 @default.
• W2020154489 cites W2048963964 @default.
• W2020154489 cites W2054663612 @default.
• W2020154489 cites W2060403220 @default.
• W2020154489 cites W2073704727 @default.
• W2020154489 cites W2084959410 @default.
• W2020154489 cites W2085247041 @default.
• W2020154489 cites W2100837269 @default.
• W2020154489 cites W2108802321 @default.
• W2020154489 cites W2242310113 @default.
• W2020154489 cites W2418323835 @default.
• W2020154489 doi "https://doi.org/10.1177/019262330002800406" @default.
• W2020154489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10930040" @default.
• W2020154489 hasPublicationYear "2000" @default.
• W2020154489 type Work @default.
• W2020154489 sameAs 2020154489 @default.
• W2020154489 citedByCount "55" @default.
• W2020154489 countsByYear W20201544892012 @default.
• W2020154489 countsByYear W20201544892013 @default.
• W2020154489 countsByYear W20201544892014 @default.
• W2020154489 countsByYear W20201544892015 @default.
• W2020154489 countsByYear W20201544892016 @default.
• W2020154489 countsByYear W20201544892017 @default.
• W2020154489 countsByYear W20201544892020 @default.
• W2020154489 countsByYear W20201544892021 @default.
• W2020154489 countsByYear W20201544892022 @default.
• W2020154489 crossrefType "journal-article" @default.
• W2020154489 hasAuthorship W2020154489A5002004328 @default.
• W2020154489 hasAuthorship W2020154489A5019798222 @default.
• W2020154489 hasAuthorship W2020154489A5041880211 @default.
• W2020154489 hasAuthorship W2020154489A5041911355 @default.
• W2020154489 hasAuthorship W2020154489A5064056142 @default.
• W2020154489 hasAuthorship W2020154489A5081837886 @default.
• W2020154489 hasAuthorship W2020154489A5082211958 @default.
• W2020154489 hasBestOaLocation W20201544891 @default.
• W2020154489 hasConcept C104317684 @default.
• W2020154489 hasConcept C114246631 @default.
• W2020154489 hasConcept C119795356 @default.
• W2020154489 hasConcept C121608353 @default.
• W2020154489 hasConcept C126322002 @default.
• W2020154489 hasConcept C134018914 @default.
• W2020154489 hasConcept C158157758 @default.
• W2020154489 hasConcept C181199279 @default.
• W2020154489 hasConcept C185592680 @default.
• W2020154489 hasConcept C202751555 @default.
• W2020154489 hasConcept C2225953 @default.
• W2020154489 hasConcept C2776200302 @default.
• W2020154489 hasConcept C2776964913 @default.
• W2020154489 hasConcept C2778019345 @default.
• W2020154489 hasConcept C2778793413 @default.
• W2020154489 hasConcept C2779838395 @default.
• W2020154489 hasConcept C2780122803 @default.
• W2020154489 hasConcept C2780228694 @default.
• W2020154489 hasConcept C2910362683 @default.
• W2020154489 hasConcept C526171541 @default.
• W2020154489 hasConcept C538909803 @default.
• W2020154489 hasConcept C55493867 @default.
• W2020154489 hasConcept C555283112 @default.
• W2020154489 hasConcept C62231903 @default.
• W2020154489 hasConcept C71924100 @default.
• W2020154489 hasConcept C79879829 @default.
• W2020154489 hasConcept C86803240 @default.
• W2020154489 hasConcept C87644729 @default.
• W2020154489 hasConceptScore W2020154489C104317684 @default.
• W2020154489 hasConceptScore W2020154489C114246631 @default.
• W2020154489 hasConceptScore W2020154489C119795356 @default.
• W2020154489 hasConceptScore W2020154489C121608353 @default.
• W2020154489 hasConceptScore W2020154489C126322002 @default.
• W2020154489 hasConceptScore W2020154489C134018914 @default.
• W2020154489 hasConceptScore W2020154489C158157758 @default.
• W2020154489 hasConceptScore W2020154489C181199279 @default.
• W2020154489 hasConceptScore W2020154489C185592680 @default.
• W2020154489 hasConceptScore W2020154489C202751555 @default.
• W2020154489 hasConceptScore W2020154489C2225953 @default.
• W2020154489 hasConceptScore W2020154489C2776200302 @default.
• W2020154489 hasConceptScore W2020154489C2776964913 @default.
• W2020154489 hasConceptScore W2020154489C2778019345 @default.
• W2020154489 hasConceptScore W2020154489C2778793413 @default.
• W2020154489 hasConceptScore W2020154489C2779838395 @default.
• W2020154489 hasConceptScore W2020154489C2780122803 @default.
• W2020154489 hasConceptScore W2020154489C2780228694 @default.

• next