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- W2020155595 endingPage "S78" @default.
- W2020155595 startingPage "S69" @default.
- W2020155595 abstract "Drug addiction is characterized by persistent behavioral and cellular plasticity throughout the brain's reward regions. Among the many neuroadaptations that occur following repeated drug administration are alterations in cell morphology including changes in dendritic spines. While this phenomenon has been well documented, the underlying molecular mechanisms are poorly understood. Here, within the context of drug abuse, we review and integrate several of the established pathways known to regulate synaptic remodeling, and discuss the contributions of neurotrophic and dopamine signaling in mediating this structural plasticity. Finally, we discuss how such upstream mechanisms could regulate actin dynamics, the common endpoint involved in structural remodeling in neurons." @default.
- W2020155595 created "2016-06-24" @default.
- W2020155595 creator A5022392689 @default.
- W2020155595 creator A5045738628 @default.
- W2020155595 creator A5049993782 @default.
- W2020155595 creator A5075816485 @default.
- W2020155595 date "2009-05-01" @default.
- W2020155595 modified "2023-09-27" @default.
- W2020155595 title "Molecular Mechanisms of Psychostimulant-induced Structural Plasticity" @default.
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