FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020156245> ?p ?o ?g. }

• W2020156245 endingPage "40" @default.
• W2020156245 startingPage "29" @default.
• W2020156245 abstract "Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus ochraceus as well as other moulds. This mycotoxin contaminates animal feed and food and is nephrotoxic for all animal species studied so far. OTA is immunosuppressive, genotoxic, teratogenic and carcinogenic. It is a structural analogue of phenylalanine and contains a chlorinated dihydroisocoumarinic moiety. Ochratoxin A inhibits protein synthesis by competition with phenylalanine in the phenylalanine-tRNA aminoacylation reaction. Recently lipid peroxidation induced by OTA has been reported, indicating that the lesions induced by this toxin could also be related to oxidative damage. An attempt to prevent its toxic effect, mainly the lipid peroxidation, has been made using aspartame (L-aspartyl-L-phenylalanine methyl ester) a structural analogue of both OTA and phenylalanine, piroxicam, a non steroidal anti-inflammatory drug and superoxide dismutase+catalase (endogenous oxygen radical scavengers). Lipid peroxidation was assayed in monkey kidney cells (Vero cells) treated by increasing concentrations of OTA (5-50 microM). After 24 h incubation OTA induced lipid peroxidation in Vero cells in a concentration dependent manner, as measured by malonaldehyde (MDA) production. The MDA production, in Vero cells, was significantly increased by 50.5% from 694.1 +/- 21.0 to 1041.5 +/- 23.5 pmol/mg of protein. In the presence of superoxide dismutase (SOD)+catalase (25 micrograms/ml each) the MDA production induced by OTA was significantly decreased. At 50 microM of OTA concentration (optimal production of MDA) the MDA production decreased from 1041.5 +/- 23.5 to 827.5 +/- 21.3 pmol/mg of protein. SOD and catalase, when applied prior to the toxin, seemed to prevent lipid peroxidation more efficiently than piroxicam (at a ten-fold higher concentration than OTA) and aspartame (at equimolar concentration). These molecules also partially prevented the OTA-induced leakage of MDA in the culture medium." @default.
• W2020156245 created "2016-06-24" @default.
• W2020156245 creator A5013253077 @default.
• W2020156245 creator A5027349537 @default.
• W2020156245 creator A5037231630 @default.
• W2020156245 date "1997-04-01" @default.
• W2020156245 modified "2023-09-25" @default.
• W2020156245 title "Prevention of lipid peroxidation induced by ochratoxin A in Vero cells in culture by several agents" @default.
• W2020156245 cites W1488003997 @default.
• W2020156245 cites W158068426 @default.
• W2020156245 cites W1598448022 @default.
• W2020156245 cites W1934175771 @default.
• W2020156245 cites W1935401387 @default.
• W2020156245 cites W1964379522 @default.
• W2020156245 cites W1973416122 @default.
• W2020156245 cites W1977082104 @default.
• W2020156245 cites W1994974723 @default.
• W2020156245 cites W2000250623 @default.
• W2020156245 cites W2003006171 @default.
• W2020156245 cites W2006946054 @default.
• W2020156245 cites W2020126595 @default.
• W2020156245 cites W2021439117 @default.
• W2020156245 cites W2022976246 @default.
• W2020156245 cites W2030514238 @default.
• W2020156245 cites W2032336668 @default.
• W2020156245 cites W2034406569 @default.
• W2020156245 cites W2038242129 @default.
• W2020156245 cites W2038809388 @default.
• W2020156245 cites W2047629158 @default.
• W2020156245 cites W2051125536 @default.
• W2020156245 cites W2058766242 @default.
• W2020156245 cites W2061828505 @default.
• W2020156245 cites W2062176029 @default.
• W2020156245 cites W2070445942 @default.
• W2020156245 cites W2072904387 @default.
• W2020156245 cites W2078770811 @default.
• W2020156245 cites W2088056575 @default.
• W2020156245 cites W2425684756 @default.
• W2020156245 cites W4293247451 @default.
• W2020156245 cites W975700395 @default.
• W2020156245 doi "https://doi.org/10.1016/s0009-2797(97)03764-2" @default.
• W2020156245 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9158693" @default.
• W2020156245 hasPublicationYear "1997" @default.
• W2020156245 type Work @default.
• W2020156245 sameAs 2020156245 @default.
• W2020156245 citedByCount "73" @default.
• W2020156245 countsByYear W20201562452012 @default.
• W2020156245 countsByYear W20201562452013 @default.
• W2020156245 countsByYear W20201562452014 @default.
• W2020156245 countsByYear W20201562452015 @default.
• W2020156245 countsByYear W20201562452016 @default.
• W2020156245 countsByYear W20201562452017 @default.
• W2020156245 countsByYear W20201562452018 @default.
• W2020156245 countsByYear W20201562452020 @default.
• W2020156245 countsByYear W20201562452021 @default.
• W2020156245 countsByYear W20201562452022 @default.
• W2020156245 crossrefType "journal-article" @default.
• W2020156245 hasAuthorship W2020156245A5013253077 @default.
• W2020156245 hasAuthorship W2020156245A5027349537 @default.
• W2020156245 hasAuthorship W2020156245A5037231630 @default.
• W2020156245 hasConcept C185592680 @default.
• W2020156245 hasConcept C2775838275 @default.
• W2020156245 hasConcept C2776008721 @default.
• W2020156245 hasConcept C2776151105 @default.
• W2020156245 hasConcept C2777431362 @default.
• W2020156245 hasConcept C2778979269 @default.
• W2020156245 hasConcept C2780829032 @default.
• W2020156245 hasConcept C31903555 @default.
• W2020156245 hasConcept C515207424 @default.
• W2020156245 hasConcept C55493867 @default.
• W2020156245 hasConcept C84699730 @default.
• W2020156245 hasConceptScore W2020156245C185592680 @default.
• W2020156245 hasConceptScore W2020156245C2775838275 @default.
• W2020156245 hasConceptScore W2020156245C2776008721 @default.
• W2020156245 hasConceptScore W2020156245C2776151105 @default.
• W2020156245 hasConceptScore W2020156245C2777431362 @default.
• W2020156245 hasConceptScore W2020156245C2778979269 @default.
• W2020156245 hasConceptScore W2020156245C2780829032 @default.
• W2020156245 hasConceptScore W2020156245C31903555 @default.
• W2020156245 hasConceptScore W2020156245C515207424 @default.
• W2020156245 hasConceptScore W2020156245C55493867 @default.
• W2020156245 hasConceptScore W2020156245C84699730 @default.
• W2020156245 hasIssue "1" @default.
• W2020156245 hasLocation W20201562451 @default.
• W2020156245 hasLocation W20201562452 @default.
• W2020156245 hasOpenAccess W2020156245 @default.
• W2020156245 hasPrimaryLocation W20201562451 @default.
• W2020156245 hasRelatedWork W1968938795 @default.
• W2020156245 hasRelatedWork W2119081986 @default.
• W2020156245 hasRelatedWork W2152536358 @default.
• W2020156245 hasRelatedWork W2158849542 @default.
• W2020156245 hasRelatedWork W2183540883 @default.
• W2020156245 hasRelatedWork W2371688276 @default.
• W2020156245 hasRelatedWork W2380016105 @default.
• W2020156245 hasRelatedWork W2416379620 @default.
• W2020156245 hasRelatedWork W2966747629 @default.
• W2020156245 hasRelatedWork W4313039917 @default.
• W2020156245 hasVolume "104" @default.

• next