FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020160421> ?p ?o ?g. }

• W2020160421 endingPage "26048" @default.
• W2020160421 startingPage "26041" @default.
• W2020160421 abstract "Metabotropic glutamate receptor 1 (mGlu1) is a G protein-coupled receptor that enhances the hydrolysis of membrane phosphoinositides. In addition to its role in synaptic transmission and plasticity, mGlu1 has been shown to be involved in neuroprotection and neurodegeneration. In this capacity, we have reported previously that in neuronal cells, mGlu1a exhibits the properties of a dependence receptor, inducing apoptosis in the absence of glutamate, while promoting neuronal survival in its presence (Pshenichkin, S., Dolińska, M., Klauzińska, M., Luchenko, V., Grajkowska, E., and Wroblewski, J. T. (2008) Neuropharmacology 55, 500-508). Here, using CHO cells expressing mGlu1a receptors, we show that the protective effect of glutamate does not rely on the classical mGlu1 signal transduction. Instead, mGlu1a protective signaling is mediated by a novel, G protein-independent, pathway which involves the activation of the MAPK pathway and a sustained phosphorylation of ERK, which is distinct from the G protein-mediated transient ERK phosphorylation. Moreover, the sustained phosphorylation of ERK and protective signaling through mGlu1a receptors require expression of beta-arrestin-1, suggesting a possible role for receptor internalization in this process. Our data reveal the existence of a novel, noncanonical signaling pathway associated with mGlu1a receptors, which mediates glutamate-induced protective signaling." @default.
• W2020160421 created "2016-06-24" @default.
• W2020160421 creator A5003024690 @default.
• W2020160421 creator A5033972385 @default.
• W2020160421 creator A5043025293 @default.
• W2020160421 creator A5086255154 @default.
• W2020160421 creator A5089588091 @default.
• W2020160421 creator A5091878324 @default.
• W2020160421 date "2010-08-01" @default.
• W2020160421 modified "2023-10-06" @default.
• W2020160421 title "The Protective Signaling of Metabotropic Glutamate Receptor 1 Is Mediated by Sustained, β-Arrestin-1-dependent ERK Phosphorylation" @default.
• W2020160421 cites W1506425398 @default.
• W2020160421 cites W1886840778 @default.
• W2020160421 cites W1893612865 @default.
• W2020160421 cites W1916850619 @default.
• W2020160421 cites W1963422225 @default.
• W2020160421 cites W1963640930 @default.
• W2020160421 cites W1963817582 @default.
• W2020160421 cites W1969762570 @default.
• W2020160421 cites W1970328692 @default.
• W2020160421 cites W1971173911 @default.
• W2020160421 cites W1971306714 @default.
• W2020160421 cites W1972174862 @default.
• W2020160421 cites W1975944686 @default.
• W2020160421 cites W1993717649 @default.
• W2020160421 cites W2003760589 @default.
• W2020160421 cites W2010877770 @default.
• W2020160421 cites W2012404266 @default.
• W2020160421 cites W2026624452 @default.
• W2020160421 cites W2029996644 @default.
• W2020160421 cites W2031010234 @default.
• W2020160421 cites W2043166209 @default.
• W2020160421 cites W2048661219 @default.
• W2020160421 cites W2053640261 @default.
• W2020160421 cites W2055457973 @default.
• W2020160421 cites W2067363750 @default.
• W2020160421 cites W2068022034 @default.
• W2020160421 cites W2078935283 @default.
• W2020160421 cites W2086262311 @default.
• W2020160421 cites W2087141223 @default.
• W2020160421 cites W2096227949 @default.
• W2020160421 cites W2100028025 @default.
• W2020160421 cites W2106042714 @default.
• W2020160421 cites W2108552018 @default.
• W2020160421 cites W2111102537 @default.
• W2020160421 cites W2114918609 @default.
• W2020160421 cites W2115476261 @default.
• W2020160421 cites W2115730131 @default.
• W2020160421 cites W2116252822 @default.
• W2020160421 cites W2119451154 @default.
• W2020160421 cites W2130632774 @default.
• W2020160421 cites W2136519986 @default.
• W2020160421 cites W2138157101 @default.
• W2020160421 cites W2144744785 @default.
• W2020160421 cites W2156638143 @default.
• W2020160421 cites W2156753857 @default.
• W2020160421 cites W4292820908 @default.
• W2020160421 doi "https://doi.org/10.1074/jbc.m110.139899" @default.
• W2020160421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2924003" @default.
• W2020160421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20566651" @default.
• W2020160421 hasPublicationYear "2010" @default.
• W2020160421 type Work @default.
• W2020160421 sameAs 2020160421 @default.
• W2020160421 citedByCount "43" @default.
• W2020160421 countsByYear W20201604212012 @default.
• W2020160421 countsByYear W20201604212013 @default.
• W2020160421 countsByYear W20201604212014 @default.
• W2020160421 countsByYear W20201604212015 @default.
• W2020160421 countsByYear W20201604212016 @default.
• W2020160421 countsByYear W20201604212017 @default.
• W2020160421 countsByYear W20201604212018 @default.
• W2020160421 countsByYear W20201604212020 @default.
• W2020160421 countsByYear W20201604212021 @default.
• W2020160421 countsByYear W20201604212023 @default.
• W2020160421 crossrefType "journal-article" @default.
• W2020160421 hasAuthorship W2020160421A5003024690 @default.
• W2020160421 hasAuthorship W2020160421A5033972385 @default.
• W2020160421 hasAuthorship W2020160421A5043025293 @default.
• W2020160421 hasAuthorship W2020160421A5086255154 @default.
• W2020160421 hasAuthorship W2020160421A5089588091 @default.
• W2020160421 hasAuthorship W2020160421A5091878324 @default.
• W2020160421 hasBestOaLocation W20201604211 @default.
• W2020160421 hasConcept C116592611 @default.
• W2020160421 hasConcept C11960822 @default.
• W2020160421 hasConcept C135285700 @default.
• W2020160421 hasConcept C170493617 @default.
• W2020160421 hasConcept C185592680 @default.
• W2020160421 hasConcept C207951395 @default.
• W2020160421 hasConcept C26702167 @default.
• W2020160421 hasConcept C2777503648 @default.
• W2020160421 hasConcept C41653306 @default.
• W2020160421 hasConcept C49051014 @default.
• W2020160421 hasConcept C55493867 @default.
• W2020160421 hasConcept C56940625 @default.
• W2020160421 hasConcept C57074206 @default.
• W2020160421 hasConcept C61174792 @default.
• W2020160421 hasConcept C62478195 @default.
• W2020160421 hasConcept C86803240 @default.

• next