Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020162800> ?p ?o ?g. }
- W2020162800 endingPage "1392" @default.
- W2020162800 startingPage "1385" @default.
- W2020162800 abstract "Objectives: This observational study aimed to explore the pathophysiology of idiopathic normal-pressure hydrocephalus (iNPH) and to evaluate the diagnostic and prognostic value of CSF biomarkers. Methods: Lumbar CSF of patients with iNPH and healthy elderly individuals (HI) and ventricular CSF (VCSF) from the patients with iNPH pre and 6 months postsurgery were analyzed by ELISA. We analyzed neurofilament light protein (NFL), myelin basic protein (MBP), a panel of β-amyloid isoforms (Aβ38, Aβ40, and Aβ42), soluble amyloid precursor protein (sAPP) isoforms sAPPα and sAPPβ, total and phosphorylated tau protein (t- and p-tau), and inflammatory markers interleukin 8, interleukin 10, and monocyte chemoattractant protein 1. Results: NFL was elevated and amyloid precursor protein (APP)–derived proteins and tau proteins were lower in patients with iNPH than in HI. Postsurgery, there was an increase of NFL, APP-derived proteins, p-tau, and albumin in VCSF, whereas levels of MBP and t-tau had decreased. Improved patients showed a greater increase of APP-derived proteins in VCSF following shunting than did those who did not improve. Conclusions: We interpret our data as iNPH pathophysiology to be characterized by a reduced periventricular metabolism and axonal degeneration but no major cortical damage." @default.
- W2020162800 created "2016-06-24" @default.
- W2020162800 creator A5001368530 @default.
- W2020162800 creator A5025313057 @default.
- W2020162800 creator A5076707725 @default.
- W2020162800 creator A5079766290 @default.
- W2020162800 date "2013-03-13" @default.
- W2020162800 modified "2023-10-18" @default.
- W2020162800 title "Idiopathic normal-pressure hydrocephalus" @default.
- W2020162800 cites W13973316 @default.
- W2020162800 cites W1916894088 @default.
- W2020162800 cites W1950910266 @default.
- W2020162800 cites W1969400128 @default.
- W2020162800 cites W1980242255 @default.
- W2020162800 cites W1990740934 @default.
- W2020162800 cites W1992805397 @default.
- W2020162800 cites W2003469292 @default.
- W2020162800 cites W2005571284 @default.
- W2020162800 cites W2005889466 @default.
- W2020162800 cites W2007824057 @default.
- W2020162800 cites W2010334223 @default.
- W2020162800 cites W2012932059 @default.
- W2020162800 cites W2012992125 @default.
- W2020162800 cites W2014240369 @default.
- W2020162800 cites W2021600851 @default.
- W2020162800 cites W2032134645 @default.
- W2020162800 cites W2044726013 @default.
- W2020162800 cites W2053973269 @default.
- W2020162800 cites W2056298279 @default.
- W2020162800 cites W2060269541 @default.
- W2020162800 cites W2065496524 @default.
- W2020162800 cites W2078097676 @default.
- W2020162800 cites W2079540265 @default.
- W2020162800 cites W2082981815 @default.
- W2020162800 cites W2083984894 @default.
- W2020162800 cites W2088264839 @default.
- W2020162800 cites W2096038692 @default.
- W2020162800 cites W2106428488 @default.
- W2020162800 cites W2117635180 @default.
- W2020162800 cites W2122282753 @default.
- W2020162800 cites W2131910251 @default.
- W2020162800 cites W2149517580 @default.
- W2020162800 cites W2152503707 @default.
- W2020162800 cites W2160965007 @default.
- W2020162800 cites W2166460680 @default.
- W2020162800 cites W4211156109 @default.
- W2020162800 cites W80974586 @default.
- W2020162800 doi "https://doi.org/10.1212/wnl.0b013e31828c2fda" @default.
- W2020162800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23486875" @default.
- W2020162800 hasPublicationYear "2013" @default.
- W2020162800 type Work @default.
- W2020162800 sameAs 2020162800 @default.
- W2020162800 citedByCount "132" @default.
- W2020162800 countsByYear W20201628002013 @default.
- W2020162800 countsByYear W20201628002014 @default.
- W2020162800 countsByYear W20201628002015 @default.
- W2020162800 countsByYear W20201628002016 @default.
- W2020162800 countsByYear W20201628002017 @default.
- W2020162800 countsByYear W20201628002018 @default.
- W2020162800 countsByYear W20201628002019 @default.
- W2020162800 countsByYear W20201628002020 @default.
- W2020162800 countsByYear W20201628002021 @default.
- W2020162800 countsByYear W20201628002022 @default.
- W2020162800 countsByYear W20201628002023 @default.
- W2020162800 crossrefType "journal-article" @default.
- W2020162800 hasAuthorship W2020162800A5001368530 @default.
- W2020162800 hasAuthorship W2020162800A5025313057 @default.
- W2020162800 hasAuthorship W2020162800A5076707725 @default.
- W2020162800 hasAuthorship W2020162800A5079766290 @default.
- W2020162800 hasConcept C10162356 @default.
- W2020162800 hasConcept C126322002 @default.
- W2020162800 hasConcept C134018914 @default.
- W2020162800 hasConcept C141071460 @default.
- W2020162800 hasConcept C142724271 @default.
- W2020162800 hasConcept C2778134817 @default.
- W2020162800 hasConcept C2778609137 @default.
- W2020162800 hasConcept C2778670691 @default.
- W2020162800 hasConcept C2779134260 @default.
- W2020162800 hasConcept C2779651940 @default.
- W2020162800 hasConcept C2780876595 @default.
- W2020162800 hasConcept C31705614 @default.
- W2020162800 hasConcept C502032728 @default.
- W2020162800 hasConcept C529278444 @default.
- W2020162800 hasConcept C71924100 @default.
- W2020162800 hasConceptScore W2020162800C10162356 @default.
- W2020162800 hasConceptScore W2020162800C126322002 @default.
- W2020162800 hasConceptScore W2020162800C134018914 @default.
- W2020162800 hasConceptScore W2020162800C141071460 @default.
- W2020162800 hasConceptScore W2020162800C142724271 @default.
- W2020162800 hasConceptScore W2020162800C2778134817 @default.
- W2020162800 hasConceptScore W2020162800C2778609137 @default.
- W2020162800 hasConceptScore W2020162800C2778670691 @default.
- W2020162800 hasConceptScore W2020162800C2779134260 @default.
- W2020162800 hasConceptScore W2020162800C2779651940 @default.
- W2020162800 hasConceptScore W2020162800C2780876595 @default.
- W2020162800 hasConceptScore W2020162800C31705614 @default.
- W2020162800 hasConceptScore W2020162800C502032728 @default.
- W2020162800 hasConceptScore W2020162800C529278444 @default.