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• W2020163229 abstract "Summary Objective Fetuin‐ A is associated with body mass index ( BMI ) as well as components of the metabolic syndrome. However, it is unclear if fetuin‐ A affects BMI or the other way around. We therefore assessed the causal association between fetuin‐ A and BMI or vice versa , utilizing a bidirectional M endelian randomization approach. Design and Methods This was a study of 2558 subjects from the E lectricity G enerating A uthority of T hailand ( EGAT ) cohort. Two polymorphisms, that is, rs2248690 in the alpha2‐ H ereman‐ S chmid glycoprotein ( AHSG ) gene and rs9939609 in the fat mass and obesity‐associated ( FTO ) gene were genotyped. Bidirectional causal models were constructed using a two‐stage least‐square instrumental variable ( IV ) regression. First, rs2248690 locus was used as the instrumental variable for the effect of circulating fetuin‐ A on BMI , and then, the FTO rs9939609 locus was used as the instrumental variable for the effect of BMI on circulating fetuin‐ A . Results Among the 2558 subjects, the prevalence of the minor AHSG (T) and FTO (A) alleles was 17·9% and 22·1%, respectively. The AHSG rs2248690 locus was highly related to serum fetuin‐A levels ( P < 0·001). Likewise, the FTO rs9939609 locus and BMI were highly associated ( P < 0·001). Mendelian randomization analyses showed that circulating fetuin‐ A , instrumented by the AHSG rs2248690 locus, was associated with BMI (coefficient = 2·26; 95% CI : 0·39, 4·12). In contrast, BMI , instrumented by the FTO rs9939609 locus, was not associated with circulating fetuin‐A (coefficient = 0·0007; 95% CI : −0·0242, 0·0256). Conclusion Our findings suggest a causal association leading from circulating fetuin‐ A to BMI . There was no evidence of reverse causality from BMI to fetuin‐A." @default.
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• W2020163229 date "2013-08-28" @default.
• W2020163229 modified "2023-10-04" @default.
• W2020163229 title "Causal relationship between body mass index and fetuin-A level in the asian population: a bidirectional mendelian randomization study" @default.
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• W2020163229 doi "https://doi.org/10.1111/cen.12303" @default.
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