Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020164483> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2020164483 endingPage "1125" @default.
- W2020164483 startingPage "1124" @default.
- W2020164483 abstract "MANY tumours induced in rodents by chemical carcinogens1 and by viruses2 are antigenic in animals of the same highly inbred strain and even in the primary autochthonous host3. It has, therefore, been suggested that an inadequacy of the immune system may be a factor in allowing the growth of an induced tumour. Much evidence has been obtained in favour of such a hypothesis. Newborn animals, which have an immature immunological system, are much more susceptible to the oncogenic effect of viruses4 and of minute doses of chemical carcinogens5 than are adult animals. Chemical carcinogens have been shown to interfere with the normal immunological defences of the host6. Thymectomy of neonatal mice7, rats8 and hamsters9 leads to some impairment of immunological function, particularly homograft reactivity, and renders animals more susceptible to the oncogenic effects of polyoma virus10 and 3,4-benzopyrene11. The experiments reported here were performed to test the oncogenic activity of another chemical carcinogen, 20-methylcholanthrene, in thymectomized mice. Inbred C57BL mice from the colony maintained at the Chester Beatty Research Institute were thymectomized or sham-thymectomized on the third day of life. At approximately five weeks of age 200 µg 20-methylcholanthrene (MC) in solution in 0.2 ml. tricaprylin was injected intramuscularly into the right thigh. The animals were examined weekly and sarcomata at the injection site were measured and recorded. Mice were killed once the sarcoma reached a size of 18–20 mm diameter, examined post mortem, and material was taken for histological investigation. The results are summarized in Table 1. Thymectomized mice were examined macroscopically and microscopically for thymus remnants, but the four mice in which these were found are not included in the table. All animals, except one sham-thymectomized mouse, developed sarcomata at the injection site." @default.
- W2020164483 created "2016-06-24" @default.
- W2020164483 creator A5033067010 @default.
- W2020164483 creator A5091102441 @default.
- W2020164483 date "1965-03-01" @default.
- W2020164483 modified "2023-10-13" @default.
- W2020164483 title "Effect of Neonatal Thymectomy on the Induction of Sarcomata in C57BL Mice" @default.
- W2020164483 cites W1982733393 @default.
- W2020164483 cites W2029722065 @default.
- W2020164483 cites W2031725498 @default.
- W2020164483 cites W2043065640 @default.
- W2020164483 cites W2058933354 @default.
- W2020164483 cites W2327490650 @default.
- W2020164483 cites W2332229456 @default.
- W2020164483 cites W2422867964 @default.
- W2020164483 cites W2441610959 @default.
- W2020164483 cites W939578225 @default.
- W2020164483 doi "https://doi.org/10.1038/2051124a0" @default.
- W2020164483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5833220" @default.
- W2020164483 hasPublicationYear "1965" @default.
- W2020164483 type Work @default.
- W2020164483 sameAs 2020164483 @default.
- W2020164483 citedByCount "59" @default.
- W2020164483 countsByYear W20201644832012 @default.
- W2020164483 countsByYear W20201644832013 @default.
- W2020164483 countsByYear W20201644832018 @default.
- W2020164483 countsByYear W20201644832020 @default.
- W2020164483 crossrefType "journal-article" @default.
- W2020164483 hasAuthorship W2020164483A5033067010 @default.
- W2020164483 hasAuthorship W2020164483A5091102441 @default.
- W2020164483 hasBestOaLocation W20201644831 @default.
- W2020164483 hasConcept C104317684 @default.
- W2020164483 hasConcept C114246631 @default.
- W2020164483 hasConcept C16685009 @default.
- W2020164483 hasConcept C203014093 @default.
- W2020164483 hasConcept C2778105408 @default.
- W2020164483 hasConcept C2779615886 @default.
- W2020164483 hasConcept C2780303067 @default.
- W2020164483 hasConcept C42407357 @default.
- W2020164483 hasConcept C54355233 @default.
- W2020164483 hasConcept C71924100 @default.
- W2020164483 hasConcept C76725341 @default.
- W2020164483 hasConcept C86803240 @default.
- W2020164483 hasConcept C8891405 @default.
- W2020164483 hasConceptScore W2020164483C104317684 @default.
- W2020164483 hasConceptScore W2020164483C114246631 @default.
- W2020164483 hasConceptScore W2020164483C16685009 @default.
- W2020164483 hasConceptScore W2020164483C203014093 @default.
- W2020164483 hasConceptScore W2020164483C2778105408 @default.
- W2020164483 hasConceptScore W2020164483C2779615886 @default.
- W2020164483 hasConceptScore W2020164483C2780303067 @default.
- W2020164483 hasConceptScore W2020164483C42407357 @default.
- W2020164483 hasConceptScore W2020164483C54355233 @default.
- W2020164483 hasConceptScore W2020164483C71924100 @default.
- W2020164483 hasConceptScore W2020164483C76725341 @default.
- W2020164483 hasConceptScore W2020164483C86803240 @default.
- W2020164483 hasConceptScore W2020164483C8891405 @default.
- W2020164483 hasIssue "4976" @default.
- W2020164483 hasLocation W20201644831 @default.
- W2020164483 hasLocation W20201644832 @default.
- W2020164483 hasOpenAccess W2020164483 @default.
- W2020164483 hasPrimaryLocation W20201644831 @default.
- W2020164483 hasRelatedWork W1141103111 @default.
- W2020164483 hasRelatedWork W147567621 @default.
- W2020164483 hasRelatedWork W1964208073 @default.
- W2020164483 hasRelatedWork W2007302024 @default.
- W2020164483 hasRelatedWork W2132877526 @default.
- W2020164483 hasRelatedWork W2332806396 @default.
- W2020164483 hasRelatedWork W3036141985 @default.
- W2020164483 hasRelatedWork W379409117 @default.
- W2020164483 hasRelatedWork W4226147513 @default.
- W2020164483 hasRelatedWork W44354121 @default.
- W2020164483 hasVolume "205" @default.
- W2020164483 isParatext "false" @default.
- W2020164483 isRetracted "false" @default.
- W2020164483 magId "2020164483" @default.
- W2020164483 workType "article" @default.