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- W2020167823 abstract "Synthetic galanin-related peptides and several galanin-(1–15)ol analogs were used to examine structure–function relationships of the N-terminal active site of galanin in more detail, using the guinea-pig ileum. The synthetic peptides examined showed their inhibitory activity on the neurally evoked circular muscle contractions with the following order of potency: rat, human and tuna galanin, galanin-(1–15)ol and [d-Trp8]galanin-(1–15)ol>Nα-acetylated galanin-(2–15)ol, [Ala6,d-Trp8]galanin-(1–15)ol, galanin-(1–15)>tuna galanin-(1–15), [d-Ala8]galanin-(1–15)ol, Nα-acetylated galanin-(1–15)ol. In contrast, [d-Thr6]galanin-(1–15)ol, [d-Tyr9]galanin-(1–15)ol and [d-Trp9]galanin-(1–15)ol were ineffective and showed no antagonistic activities to galanin. These results suggest that the l-configuration at positions 6 and 9 seems to be important for the inhibitory action of galanin on the neurally evoked guinea-pig circular muscle contractions." @default.
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- W2020167823 title "Role of N-terminal active sites of galanin in neurally evoked circular muscle contractions in the guinea-pig ileum" @default.
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- W2020167823 doi "https://doi.org/10.1016/s0014-2999(97)10109-1" @default.
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