Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020169731> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2020169731 endingPage "515" @default.
- W2020169731 startingPage "515" @default.
- W2020169731 abstract "Expression of renal aquaporins 1, 2, and 3 in a rat model of cisplatin-induced polyuria.Cisplatin (CP)-induced polyuria in rats is attributed to decreased medullary hypertonicity and/or an end-organ resistance to vasopressin. However, the roles of renal aquaporins (AQPs) have not yet been explored.Male Sprague-Dawley rats (230 to 245 g) received either a single injection of CP (5 mg/kg, N = 4) or saline (N = 4) intraperitoneally five days before sacrifice. Urine, blood, and kidney samples were analyzed.Platinum accumulated in the cortex and outer medulla of CP-treated rats (39.05 ± 7.50 and 36.48 ± 12.44 μg/g vs. 2.52 ± 0.43 and 1.87 ± 0.84 μg/g dry tissue in controls, respectively). Histologically, tubular damage and decreased AQP1 immunolabeling were detected in the S3 segment of proximal tubules. CP treatment caused 4.4- and 4.8-fold increases, respectively, in blood urea nitrogen and urine volume, and a 4.4-fold decrease in urine osmolality. Immunoblots showed that AQP2 and AQP3 were significantly reduced to 33 ± 10% (P < 0.001) and 69 ± 11% (P < 0.05), respectively, in the inner medulla of CP-treated rats. Immunocytochemical analysis showed a decrease in AQP2 labeling in the inner medulla of CP-treated rats. Northern hybridization revealed a 33 ± 11% (P < 0.002) decrease in AQP2 mRNA expression in the inner medulla of CP-treated rats. AQP1 protein expression levels were modestly (67 ± 7%, P = 0.057) and significantly (53 ± 13%, P < 0.007) decreased in outer and inner medullae, respectively, of CP-treated rats.CP-induced polyuria in rats is associated with a significant decrease in the expression of collecting duct (AQP2 and AQP3) and proximal nephron and microvascular (AQP1) water channels in the inner medulla." @default.
- W2020169731 created "2016-06-24" @default.
- W2020169731 creator A5010007659 @default.
- W2020169731 creator A5017722455 @default.
- W2020169731 creator A5036436163 @default.
- W2020169731 creator A5039500138 @default.
- W2020169731 creator A5043861399 @default.
- W2020169731 creator A5077165427 @default.
- W2020169731 date "2015-04-01" @default.
- W2020169731 modified "2023-10-06" @default.
- W2020169731 title "Possible role of TRPV-1 and AQPs in the regulation of trophoblast cell volume" @default.
- W2020169731 doi "https://doi.org/10.1016/j.placenta.2015.01.536" @default.
- W2020169731 hasPublicationYear "2015" @default.
- W2020169731 type Work @default.
- W2020169731 sameAs 2020169731 @default.
- W2020169731 citedByCount "0" @default.
- W2020169731 crossrefType "journal-article" @default.
- W2020169731 hasAuthorship W2020169731A5010007659 @default.
- W2020169731 hasAuthorship W2020169731A5017722455 @default.
- W2020169731 hasAuthorship W2020169731A5036436163 @default.
- W2020169731 hasAuthorship W2020169731A5039500138 @default.
- W2020169731 hasAuthorship W2020169731A5043861399 @default.
- W2020169731 hasAuthorship W2020169731A5077165427 @default.
- W2020169731 hasConcept C126322002 @default.
- W2020169731 hasConcept C127413603 @default.
- W2020169731 hasConcept C134018914 @default.
- W2020169731 hasConcept C185592680 @default.
- W2020169731 hasConcept C201289731 @default.
- W2020169731 hasConcept C2775845273 @default.
- W2020169731 hasConcept C2776370428 @default.
- W2020169731 hasConcept C2778534349 @default.
- W2020169731 hasConcept C2780091579 @default.
- W2020169731 hasConcept C2780180277 @default.
- W2020169731 hasConcept C2780512574 @default.
- W2020169731 hasConcept C555293320 @default.
- W2020169731 hasConcept C71924100 @default.
- W2020169731 hasConcept C78519656 @default.
- W2020169731 hasConcept C85562759 @default.
- W2020169731 hasConcept C86803240 @default.
- W2020169731 hasConceptScore W2020169731C126322002 @default.
- W2020169731 hasConceptScore W2020169731C127413603 @default.
- W2020169731 hasConceptScore W2020169731C134018914 @default.
- W2020169731 hasConceptScore W2020169731C185592680 @default.
- W2020169731 hasConceptScore W2020169731C201289731 @default.
- W2020169731 hasConceptScore W2020169731C2775845273 @default.
- W2020169731 hasConceptScore W2020169731C2776370428 @default.
- W2020169731 hasConceptScore W2020169731C2778534349 @default.
- W2020169731 hasConceptScore W2020169731C2780091579 @default.
- W2020169731 hasConceptScore W2020169731C2780180277 @default.
- W2020169731 hasConceptScore W2020169731C2780512574 @default.
- W2020169731 hasConceptScore W2020169731C555293320 @default.
- W2020169731 hasConceptScore W2020169731C71924100 @default.
- W2020169731 hasConceptScore W2020169731C78519656 @default.
- W2020169731 hasConceptScore W2020169731C85562759 @default.
- W2020169731 hasConceptScore W2020169731C86803240 @default.
- W2020169731 hasIssue "4" @default.
- W2020169731 hasLocation W20201697311 @default.
- W2020169731 hasOpenAccess W2020169731 @default.
- W2020169731 hasPrimaryLocation W20201697311 @default.
- W2020169731 hasRelatedWork W1979292275 @default.
- W2020169731 hasRelatedWork W2003587549 @default.
- W2020169731 hasRelatedWork W2011789834 @default.
- W2020169731 hasRelatedWork W2057585929 @default.
- W2020169731 hasRelatedWork W2070818631 @default.
- W2020169731 hasRelatedWork W2071155830 @default.
- W2020169731 hasRelatedWork W2093712015 @default.
- W2020169731 hasRelatedWork W2127850904 @default.
- W2020169731 hasRelatedWork W2142502531 @default.
- W2020169731 hasRelatedWork W2182139610 @default.
- W2020169731 hasVolume "36" @default.
- W2020169731 isParatext "false" @default.
- W2020169731 isRetracted "false" @default.
- W2020169731 magId "2020169731" @default.
- W2020169731 workType "article" @default.