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- W2020169838 abstract "Cultured myotubes and freshly dissociated muscle fibres from adult rats were exposed to calcitonin gene-related peptide (CGRP) and studied by patch-clamp recording during the peptide-induced maximal accumulation of cellular cyclic AMP (cAMP). Acetylcholine receptor- (AChR-) channel properties in myotubes were not modified by the presence of CGRP (10 -7 M). The peptide, applied to the non-patched membrane, significantly increased the variance of the AChR-channel amplitude distribution at the synaptic region of muscle fibres, and three classes of AChR-channels were resolved immediately after peptide application. AChR-channels at extrasynaptic regions of fibres from denervated muscles were unaffected by CGRP. It is suggested that CGRP may regulate the synaptic AChR-channel conductance through second messenger systems." @default.
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- W2020169838 date "1988-08-23" @default.
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- W2020169838 title "Effects of calcitonin gene-related peptide on synaptic acetylcholine receptor-channels in rat muscle fibres" @default.
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- W2020169838 doi "https://doi.org/10.1098/rspb.1988.0052" @default.
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