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• W2020174435 abstract "Sfrp is a secreted Wnt antagonist that directly interacts with Wnt ligand. We show here that inactivation of Sfrp1, Sfrp2, and Sfrp5 leads to fused somites formation in early-somite mouse embryos, simultaneously resulting in defective convergent extension (CE), which causes severe shortening of the anteroposterior axis. These observations indicate the redundant roles of Sfrp1, Sfrp2, and Sfrp5 in early trunk formation. The roles of the Sfrps were genetically distinguished in terms of the regulation of Wnt pathways. Genetic analysis combining Sfrps mutants and Loop-tail mice revealed the involvement of Sfrps in CE through the regulation of the planar cell polarity pathway. Furthermore, Dkk1-deficient embryos carrying Sfrp1 homozygous and Sfrp2 heterozygous mutations display irregular somites and indistinct intersomitic boundaries, which indicates that Sfrps-mediated inhibition of the Wnt/β-catenin pathway is necessary for somitogenesis. Our results suggest that Sfrps regulation of the canonical and noncanonical pathways is essential for proper trunk formation. genesis 46:92–103, 2008. © 2008 Wiley-Liss, Inc." @default.
• W2020174435 created "2016-06-24" @default.
• W2020174435 creator A5020029139 @default.
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• W2020174435 creator A5065082244 @default.
• W2020174435 date "2008-01-01" @default.
• W2020174435 modified "2023-10-07" @default.
• W2020174435 title "Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/β-catenin and the planar cell polarity pathways during early trunk formation in mouse" @default.
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• W2020174435 doi "https://doi.org/10.1002/dvg.20369" @default.
• W2020174435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18257070" @default.
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