Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020174772> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2020174772 endingPage "245" @default.
- W2020174772 startingPage "237" @default.
- W2020174772 abstract "The hypothesis that decreased T cell function in the elderly involves an increased number of less differentiated T cells was examined. Three markers known to change during thymocyte development were analyzed; ratio of adenosine deaminase (ADA) to purine nucleoside phosphorylase (PNP), lactate dehydrogenase (LD) H/M subunit ratios and the T cell associated antigens, T3, T4, T8 and T10. Cells tested were from 10 old (greater than 75 years) and 10 young (less than 35 years) persons with equal numbers of males and females in each group. Before analysis, cells were purified into three groups; unfractionated, and monocyte depleted T cell and B cell enriched populations. Results for ADA/PNP ratios showed no significant differences between old and young in any of the fractions analyzed. H/M ratios however, were significantly reduced in all three fractions from old donors when compared with young. Surface marker distribution pattern as illustrated by the T3 - (T4 + T8) difference was lower in samples from old donors but not significantly so. There was a very significant reduction in percent cells positive for T3 in all three fractions from old persons. Although some of the changes seen in these markers could be due to a failure of normal differentiation, they could also be caused by the general phenomenon of altered gene expression known to occur with advanced age in a variety of non-lymphoid cells. The absence of any difference in the ADA/PNP ratio suggests that T cell dysfunction in the elderly may not be due to increased numbers of less differentiated cells as a result of thymic involution." @default.
- W2020174772 created "2016-06-24" @default.
- W2020174772 creator A5006924420 @default.
- W2020174772 creator A5013929215 @default.
- W2020174772 creator A5036745866 @default.
- W2020174772 creator A5085948374 @default.
- W2020174772 date "1986-02-01" @default.
- W2020174772 modified "2023-10-18" @default.
- W2020174772 title "Do immature T cells accumulate in advanced age?" @default.
- W2020174772 cites W1516036985 @default.
- W2020174772 cites W1528683573 @default.
- W2020174772 cites W1569391610 @default.
- W2020174772 cites W1999888185 @default.
- W2020174772 cites W2014575274 @default.
- W2020174772 cites W2022037823 @default.
- W2020174772 cites W2023959073 @default.
- W2020174772 cites W2034876523 @default.
- W2020174772 cites W2042221539 @default.
- W2020174772 cites W2053412939 @default.
- W2020174772 cites W2058220179 @default.
- W2020174772 cites W2066952976 @default.
- W2020174772 cites W2085606970 @default.
- W2020174772 cites W2098822268 @default.
- W2020174772 cites W2124967878 @default.
- W2020174772 doi "https://doi.org/10.1016/0047-6374(86)90049-7" @default.
- W2020174772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3086635" @default.
- W2020174772 hasPublicationYear "1986" @default.
- W2020174772 type Work @default.
- W2020174772 sameAs 2020174772 @default.
- W2020174772 citedByCount "13" @default.
- W2020174772 crossrefType "journal-article" @default.
- W2020174772 hasAuthorship W2020174772A5006924420 @default.
- W2020174772 hasAuthorship W2020174772A5013929215 @default.
- W2020174772 hasAuthorship W2020174772A5036745866 @default.
- W2020174772 hasAuthorship W2020174772A5085948374 @default.
- W2020174772 hasConcept C126322002 @default.
- W2020174772 hasConcept C134018914 @default.
- W2020174772 hasConcept C147483822 @default.
- W2020174772 hasConcept C153911025 @default.
- W2020174772 hasConcept C167672396 @default.
- W2020174772 hasConcept C181199279 @default.
- W2020174772 hasConcept C203014093 @default.
- W2020174772 hasConcept C2776476023 @default.
- W2020174772 hasConcept C2776991684 @default.
- W2020174772 hasConcept C2777318727 @default.
- W2020174772 hasConcept C2778954852 @default.
- W2020174772 hasConcept C34628245 @default.
- W2020174772 hasConcept C55493867 @default.
- W2020174772 hasConcept C71615608 @default.
- W2020174772 hasConcept C71924100 @default.
- W2020174772 hasConcept C86803240 @default.
- W2020174772 hasConceptScore W2020174772C126322002 @default.
- W2020174772 hasConceptScore W2020174772C134018914 @default.
- W2020174772 hasConceptScore W2020174772C147483822 @default.
- W2020174772 hasConceptScore W2020174772C153911025 @default.
- W2020174772 hasConceptScore W2020174772C167672396 @default.
- W2020174772 hasConceptScore W2020174772C181199279 @default.
- W2020174772 hasConceptScore W2020174772C203014093 @default.
- W2020174772 hasConceptScore W2020174772C2776476023 @default.
- W2020174772 hasConceptScore W2020174772C2776991684 @default.
- W2020174772 hasConceptScore W2020174772C2777318727 @default.
- W2020174772 hasConceptScore W2020174772C2778954852 @default.
- W2020174772 hasConceptScore W2020174772C34628245 @default.
- W2020174772 hasConceptScore W2020174772C55493867 @default.
- W2020174772 hasConceptScore W2020174772C71615608 @default.
- W2020174772 hasConceptScore W2020174772C71924100 @default.
- W2020174772 hasConceptScore W2020174772C86803240 @default.
- W2020174772 hasIssue "3" @default.
- W2020174772 hasLocation W20201747721 @default.
- W2020174772 hasLocation W20201747722 @default.
- W2020174772 hasOpenAccess W2020174772 @default.
- W2020174772 hasPrimaryLocation W20201747721 @default.
- W2020174772 hasRelatedWork W1978639835 @default.
- W2020174772 hasRelatedWork W2017770252 @default.
- W2020174772 hasRelatedWork W2056270585 @default.
- W2020174772 hasRelatedWork W2058991568 @default.
- W2020174772 hasRelatedWork W2117564488 @default.
- W2020174772 hasRelatedWork W2130981205 @default.
- W2020174772 hasRelatedWork W2284240597 @default.
- W2020174772 hasRelatedWork W2284724167 @default.
- W2020174772 hasRelatedWork W2320914227 @default.
- W2020174772 hasRelatedWork W2399068952 @default.
- W2020174772 hasVolume "33" @default.
- W2020174772 isParatext "false" @default.
- W2020174772 isRetracted "false" @default.
- W2020174772 magId "2020174772" @default.
- W2020174772 workType "article" @default.