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• W2020175674 abstract "Virus particle formation of HIV-1 is driven by the viral structural protein Gag. In most cell types including T cells, Gag assembles into virus particles at the plasma membrane whereas, in HIV-1-infected macrophages, Gag and virus particles have been shown to accumulate in intracellular vesicles. At the moment, what causes this difference between cell types remains unknown. However, recent findings on the relationships between Gag and the cellular membrane system have substantially increased our understanding of the mechanisms by which sites of virus assembly are determined. I will review our current knowledge regarding the roles played by endosomal trafficking pathways, membrane microdomains, and plasma membrane lipids, and discuss the physiological significance of the interactions between Gag and specific membrane structures." @default.
• W2020175674 created "2016-06-24" @default.
• W2020175674 creator A5062424208 @default.
• W2020175674 date "2007-01-01" @default.
• W2020175674 modified "2023-09-28" @default.
• W2020175674 title "Subcellular Locations at which HIV-1 Assembles." @default.
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• W2020175674 doi "https://doi.org/10.2222/jsv.57.9" @default.
• W2020175674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18040150" @default.
• W2020175674 hasPublicationYear "2007" @default.
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