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• W2020179045 abstract "Cholestyramine is a first-generation bile acid sequestrant (BAS) and antihyperlipidemic agent that currently has limited use because of its relatively weak effect on lowering low density-lipoprotein (LDL)-cholesterol (C) and poor tolerability. The current first choice drugs for hyper-LDL-cholesterolemia are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) because of their strong LDL-C lowering effects and efficacy in prevention of cardiovascular disease. However, after lowering the target levels of LDL-C in very high risk patients, combination therapy with statins and other antihyperlipidemic drugs may become more important for treatment of hyper-LDL-cholesterolemia. Second-generation BASs such as colesevelam and colestimide have a glucose-lowering effect and improved tolerance, which has led to re-evaluation of their utility in combination with statins or antidiabetic agents." @default.
• W2020179045 created "2016-06-24" @default.
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• W2020179045 date "2010-01-01" @default.
• W2020179045 modified "2023-10-18" @default.
• W2020179045 title "Role of bile acid sequestrants in the treatment of type 2 diabetes" @default.
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• W2020179045 doi "https://doi.org/10.4239/wjd.v1.i5.146" @default.
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