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- W2020179062 abstract "Great hope has been given to micronutrients as anticancer agents, since they present natural compounds with beneficial effects for normal cells and tissues. One of these is vitamin E (VE), an antioxidant and an essential component of biological membranes and circulating lipoproteins. In spite of a number of epidemiological and intervention studies, little or no correlation between VE intake and incidence of cancer has been found. Recent reports have identified a redox-silent analogue of VE, α-tocopheryl succinate (α-TOS), as a potent anticancer agent with a unique structure and pharmacokinetics in vivo. α-TOS is highly selective for malignant cells, inducing them into apoptotic death largely via the mitochondrial route. The molecule of α-TOS may be modified so that analogues with higher activity are generated. Finally, α-TOS and similar agents are metabolised to VE, thereby yielding a compound with a secondary beneficial activity. Thus, α-TOS epitomises a group of novel compounds that hold substantial promise as future anticancer drugs. The reasons for this optimistic notion are discussed in the following paragraphs." @default.
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- W2020179062 date "2003-11-01" @default.
- W2020179062 modified "2023-10-18" @default.
- W2020179062 title "Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity" @default.
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- W2020179062 doi "https://doi.org/10.1038/sj.bjc.6601360" @default.
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