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- W2020180197 endingPage "1358" @default.
- W2020180197 startingPage "1348" @default.
- W2020180197 abstract "Unlike normal somatic cells, human embryonic stem cells (hESCs) can proliferate indefinitely in culture in an undifferentiated state where they do not appear to undergo senescence and yet remain nontransformed. Cells maintain their pluripotency both in vivo and in vitro, exhibit high telomerase activity, and maintain telomere length after prolonged in vitro culture. Thus, hESCs may provide an unlimited cell source for replacement in a number of aging-related neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease as well as other neurological disorders including spinal cord injuries. The ability of hESCs to bypass senescence is lost as hESCs differentiate into fully differentiated somatic cells. Evidence has been accumulated that differences in telomere length, telomerase activity, cell cycle signaling, DNA repair ability, as well as the lack of genomic, mitochondrial and epigenetic changes, may contribute to the lack of senescence in hESC. In this manuscript, we will review recent advances in characterizing hESCs and monitoring changes in these aspects in prolonged cultures. We will focus on the potential roles of several cellular pathways including the telomerase, p53 and the Rb pathways in escaping senescence in hESCs. We will also discuss the genomic and epigenetic changes in long-term hESC culture and their potential roles in bypassing senescence." @default.
- W2020180197 created "2016-06-24" @default.
- W2020180197 creator A5009697908 @default.
- W2020180197 creator A5059970716 @default.
- W2020180197 date "2007-04-01" @default.
- W2020180197 modified "2023-10-11" @default.
- W2020180197 title "Human embryonic stem cells: Long term stability, absence of senescence and a potential cell source for neural replacement" @default.
- W2020180197 cites W107156070 @default.
- W2020180197 cites W137726529 @default.
- W2020180197 cites W1532405552 @default.
- W2020180197 cites W1544651034 @default.
- W2020180197 cites W1574658543 @default.
- W2020180197 cites W1591789003 @default.
- W2020180197 cites W1650754258 @default.
- W2020180197 cites W1658682427 @default.
- W2020180197 cites W1963559963 @default.
- W2020180197 cites W1968325292 @default.
- W2020180197 cites W1972992428 @default.
- W2020180197 cites W1973186568 @default.
- W2020180197 cites W1979610420 @default.
- W2020180197 cites W1982501879 @default.
- W2020180197 cites W1984374449 @default.
- W2020180197 cites W1989780518 @default.
- W2020180197 cites W1990039630 @default.
- W2020180197 cites W1992525863 @default.
- W2020180197 cites W1998492363 @default.
- W2020180197 cites W2001258296 @default.
- W2020180197 cites W2002508731 @default.
- W2020180197 cites W2003137016 @default.
- W2020180197 cites W2004247546 @default.
- W2020180197 cites W2004314923 @default.
- W2020180197 cites W2006048326 @default.
- W2020180197 cites W2018369441 @default.
- W2020180197 cites W2024209230 @default.
- W2020180197 cites W2025648662 @default.
- W2020180197 cites W2026856852 @default.
- W2020180197 cites W2028361915 @default.
- W2020180197 cites W2036293216 @default.
- W2020180197 cites W2036385196 @default.
- W2020180197 cites W2039188344 @default.
- W2020180197 cites W2041316642 @default.
- W2020180197 cites W2042160143 @default.
- W2020180197 cites W2042699407 @default.
- W2020180197 cites W2045899482 @default.
- W2020180197 cites W2050560941 @default.
- W2020180197 cites W2053704023 @default.
- W2020180197 cites W2054823635 @default.
- W2020180197 cites W2055335794 @default.
- W2020180197 cites W2056022475 @default.
- W2020180197 cites W2056707698 @default.
- W2020180197 cites W2060134459 @default.
- W2020180197 cites W2062395030 @default.
- W2020180197 cites W2064906213 @default.
- W2020180197 cites W2065796189 @default.
- W2020180197 cites W2066170631 @default.
- W2020180197 cites W2066413879 @default.
- W2020180197 cites W2070672203 @default.
- W2020180197 cites W2073251736 @default.
- W2020180197 cites W2074188486 @default.
- W2020180197 cites W2075084906 @default.
- W2020180197 cites W2076477831 @default.
- W2020180197 cites W2080608068 @default.
- W2020180197 cites W2083763893 @default.
- W2020180197 cites W2085593164 @default.
- W2020180197 cites W2086943348 @default.
- W2020180197 cites W2086992094 @default.
- W2020180197 cites W2087404852 @default.
- W2020180197 cites W2090547063 @default.
- W2020180197 cites W2091914447 @default.
- W2020180197 cites W2092476887 @default.
- W2020180197 cites W2094127052 @default.
- W2020180197 cites W2105144878 @default.
- W2020180197 cites W2105896701 @default.
- W2020180197 cites W2108482850 @default.
- W2020180197 cites W2108993318 @default.
- W2020180197 cites W2109881276 @default.
- W2020180197 cites W2119549041 @default.
- W2020180197 cites W2123105653 @default.
- W2020180197 cites W2125547572 @default.
- W2020180197 cites W2130883309 @default.
- W2020180197 cites W2131433803 @default.
- W2020180197 cites W2133501984 @default.
- W2020180197 cites W2134027309 @default.
- W2020180197 cites W2137019827 @default.
- W2020180197 cites W2138088258 @default.
- W2020180197 cites W2138442302 @default.
- W2020180197 cites W2139975555 @default.
- W2020180197 cites W2150051201 @default.
- W2020180197 cites W2154938844 @default.
- W2020180197 cites W2156875724 @default.
- W2020180197 cites W2160908595 @default.
- W2020180197 cites W2162439328 @default.
- W2020180197 cites W2166081779 @default.
- W2020180197 cites W2170578522 @default.
- W2020180197 cites W2171862017 @default.
- W2020180197 cites W2316434439 @default.
- W2020180197 cites W2323812734 @default.
- W2020180197 cites W2340617757 @default.