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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020181303> ?p ?o ?g. }

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• W2020181303 abstract "G-Protein-coupled receptors (GPCRs) adopt various functionally relevant conformational states in cell signaling processes. Recently determined crystal structures of rhodopsin and the β2-adrenergic receptor (β2-AR) offer insight into previously uncharacterized active conformations, but the molecular states of these GPCRs are likely to contain both inactive and active-like conformational elements. We have identified conformational rearrangements in the dynamics of the TM7−HX8 segment that relate to the properties of the conserved NPxxY(x)5,6F motif and show that they can be used to identify active state-like conformational elements in the corresponding regions of the new structures of rhodopsin and the β2-AR." @default.
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• W2020181303 date "2008-06-18" @default.
• W2020181303 modified "2023-10-12" @default.
• W2020181303 title "Active State-like Conformational Elements in the β₂-AR and a Photoactivated Intermediate of Rhodopsin Identified by Dynamic Properties of GPCRs" @default.
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• W2020181303 doi "https://doi.org/10.1021/bi800442g" @default.
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