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- W2020182885 endingPage "e969100" @default.
- W2020182885 startingPage "e969100" @default.
- W2020182885 abstract "Epithelial adhesion molecules play essential roles in regulating cellular function and maintaining mucosal tissue homeostasis. Some form epithelial junctional complexes to provide structural support for epithelial monolayers and act as a selectively permeable barrier separating luminal contents from the surrounding tissue. Others serve as docking structures for invading viruses and bacteria, while also regulating the immune response. They can either obstruct or serve as footholds for the immune cells recruited to mucosal surfaces. Currently, it is well appreciated that adhesion molecules collectively serve as environmental cue sensors and trigger signaling events to regulate epithelial function through their association with the cell cytoskeleton and various intracellular adapter proteins. Immune cells, particularly neutrophils (PMN) during transepithelial migration (TEM), can modulate adhesion molecule expression, conformation, and distribution, significantly impacting epithelial function and tissue homeostasis. This review discusses the roles of key intestinal epithelial adhesion molecules in regulating PMN trafficking and outlines the potential consequences on epithelial function." @default.
- W2020182885 created "2016-06-24" @default.
- W2020182885 creator A5056514518 @default.
- W2020182885 creator A5074708797 @default.
- W2020182885 date "2014-09-26" @default.
- W2020182885 modified "2023-10-16" @default.
- W2020182885 title "Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration" @default.
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