FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020183182> ?p ?o ?g. }

• W2020183182 endingPage "261" @default.
• W2020183182 startingPage "255" @default.
• W2020183182 abstract "Different animal models have been developed to study the pathogenesis and treatment of obliterative airway disease (OAD). Here we describe the techniques of heterotopic and orthotopic tracheal transplantations in the rat, comparing the kinetics of systemic host immune response and of histopathologic OAD development. Heterotopic and orthotopic tracheal transplantations were performed in both allogeneic (Brown Norway-to-Lewis) and syngeneic (Lewis-to-Lewis) models. Grafts were harvested after 7, 30, and 60 days post-transplant for histologic evaluation and analysis of host cellular and humoral response. Syngeneic tracheal grafts did not develop luminal obliteration and were morphologically indistinguishable from native tracheas. In heterotopic allografts, airway epithelium was rapidly destroyed and OAD progressed with complete luminal occlusion by 30 days. Orthotopic allografts showed enhanced early infiltration (1298 ± 45 vs. 674 ± 75 cells/high power field, p < 0.001) with concomitant greater day 7 luminal narrowing (45 ± 6% vs. 14 ± 3%, p < 0.001). In this model, donor-type BN epithelium (62 ± 17%, 21 ± 19%, and 1 ± 1% on days 7, 30, and 60) was gradually replaced by recipient-type epithelial cells (2 ± 4%, 70 ± 22%, and 98 ± 2%). OAD developed with circular orientation of cells and connective tissue fibers to 45 ± 6% obliteration by day 60. Cellular host response, as determined by IFN-γ-ELISPOT assay (548 ± 132 vs. 402 ± 197 spots, p = 0.046) and anti-donor alloreactive IgM antibody production (2827 ± 148 vs. 1565 ± 393 mean channel fluorescence, p < 0.001) were significantly stronger in rats bearing orthotopic vs. heterotopic allografts. The orthotopic tracheal transplantation model may be more representative of OAD found in human lung transplant recipients and we therefore encourage the wider use of this model." @default.
• W2020183182 created "2016-06-24" @default.
• W2020183182 creator A5008505299 @default.
• W2020183182 creator A5012668274 @default.
• W2020183182 creator A5026482525 @default.
• W2020183182 creator A5040644146 @default.
• W2020183182 creator A5054247350 @default.
• W2020183182 creator A5061891849 @default.
• W2020183182 creator A5076167190 @default.
• W2020183182 date "2007-06-01" @default.
• W2020183182 modified "2023-09-23" @default.
• W2020183182 title "Techniques for experimental heterotopic and orthotopic tracheal transplantations — When to use which model?" @default.
• W2020183182 cites W1570160369 @default.
• W2020183182 cites W1696337576 @default.
• W2020183182 cites W1865826530 @default.
• W2020183182 cites W1984965236 @default.
• W2020183182 cites W1997737844 @default.
• W2020183182 cites W1998482426 @default.
• W2020183182 cites W2005804757 @default.
• W2020183182 cites W2020638406 @default.
• W2020183182 cites W2031777806 @default.
• W2020183182 cites W2037635676 @default.
• W2020183182 cites W2038091717 @default.
• W2020183182 cites W2045656371 @default.
• W2020183182 cites W2046362682 @default.
• W2020183182 cites W2048514182 @default.
• W2020183182 cites W2052217008 @default.
• W2020183182 cites W2052687680 @default.
• W2020183182 cites W2055797364 @default.
• W2020183182 cites W2059992850 @default.
• W2020183182 cites W2069005529 @default.
• W2020183182 cites W2070159725 @default.
• W2020183182 cites W2073856089 @default.
• W2020183182 cites W2078654417 @default.
• W2020183182 cites W2079137031 @default.
• W2020183182 cites W2088864580 @default.
• W2020183182 cites W2089422744 @default.
• W2020183182 cites W2112421342 @default.
• W2020183182 cites W2136992496 @default.
• W2020183182 cites W2141048307 @default.
• W2020183182 cites W2141523423 @default.
• W2020183182 cites W2154020009 @default.
• W2020183182 cites W2952917794 @default.
• W2020183182 doi "https://doi.org/10.1016/j.trim.2007.01.009" @default.
• W2020183182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17493528" @default.
• W2020183182 hasPublicationYear "2007" @default.
• W2020183182 type Work @default.
• W2020183182 sameAs 2020183182 @default.
• W2020183182 citedByCount "15" @default.
• W2020183182 countsByYear W20201831822012 @default.
• W2020183182 countsByYear W20201831822013 @default.
• W2020183182 countsByYear W20201831822014 @default.
• W2020183182 countsByYear W20201831822015 @default.
• W2020183182 countsByYear W20201831822016 @default.
• W2020183182 crossrefType "journal-article" @default.
• W2020183182 hasAuthorship W2020183182A5008505299 @default.
• W2020183182 hasAuthorship W2020183182A5012668274 @default.
• W2020183182 hasAuthorship W2020183182A5026482525 @default.
• W2020183182 hasAuthorship W2020183182A5040644146 @default.
• W2020183182 hasAuthorship W2020183182A5054247350 @default.
• W2020183182 hasAuthorship W2020183182A5061891849 @default.
• W2020183182 hasAuthorship W2020183182A5076167190 @default.
• W2020183182 hasConcept C105922876 @default.
• W2020183182 hasConcept C141071460 @default.
• W2020183182 hasConcept C142724271 @default.
• W2020183182 hasConcept C167672396 @default.
• W2020183182 hasConcept C203014093 @default.
• W2020183182 hasConcept C2779053233 @default.
• W2020183182 hasConcept C2911091166 @default.
• W2020183182 hasConcept C71924100 @default.
• W2020183182 hasConcept C8891405 @default.
• W2020183182 hasConceptScore W2020183182C105922876 @default.
• W2020183182 hasConceptScore W2020183182C141071460 @default.
• W2020183182 hasConceptScore W2020183182C142724271 @default.
• W2020183182 hasConceptScore W2020183182C167672396 @default.
• W2020183182 hasConceptScore W2020183182C203014093 @default.
• W2020183182 hasConceptScore W2020183182C2779053233 @default.
• W2020183182 hasConceptScore W2020183182C2911091166 @default.
• W2020183182 hasConceptScore W2020183182C71924100 @default.
• W2020183182 hasConceptScore W2020183182C8891405 @default.
• W2020183182 hasIssue "4" @default.
• W2020183182 hasLocation W20201831821 @default.
• W2020183182 hasLocation W20201831822 @default.
• W2020183182 hasOpenAccess W2020183182 @default.
• W2020183182 hasPrimaryLocation W20201831821 @default.
• W2020183182 hasRelatedWork W1905845355 @default.
• W2020183182 hasRelatedWork W2242587286 @default.
• W2020183182 hasRelatedWork W2374598947 @default.
• W2020183182 hasRelatedWork W2467457927 @default.
• W2020183182 hasRelatedWork W2992709694 @default.
• W2020183182 hasRelatedWork W3031151340 @default.
• W2020183182 hasRelatedWork W4238599390 @default.
• W2020183182 hasRelatedWork W4245540480 @default.
• W2020183182 hasRelatedWork W4286856427 @default.
• W2020183182 hasRelatedWork W4311499194 @default.
• W2020183182 hasVolume "17" @default.
• W2020183182 isParatext "false" @default.
• W2020183182 isRetracted "false" @default.

• next