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• W2020183931 abstract "Upon exposure to ionizing radiation, DNA undergoes a variety of modifications including the production of a covalent bond between the nucleobase thymine and aromatic amino acids. In this work, electrospray ionization-mass spectrometry(ESI-MS) was used to identify the gamma radiation-induced covalent cross-linking of model peptides (sequence YPPW and pYPPW) with the nucleobase thymine. Tandem electrospray ionization-mass spectrometry (ESI-MSn) was employed to investigate the cross-linking sites. The results showed that irrespective of whether tyrosine was phosphorylated or not, the nucleobase thymine was cross-linked with the tryptophan residue. Possible cross-linking mechanisms are proposed by investigating the related mass peaks. Copyright © 2006 John Wiley & Sons, Ltd." @default.
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• W2020183931 date "2006-01-01" @default.
• W2020183931 modified "2023-09-25" @default.
• W2020183931 title "Identification of radiation-induced cross-linking between thymine and tryptophan by electrospray ionization-mass spectrometry" @default.
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• W2020183931 doi "https://doi.org/10.1002/jms.1090" @default.
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