FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020184127> ?p ?o ?g. }

• W2020184127 endingPage "914" @default.
• W2020184127 startingPage "907" @default.
• W2020184127 abstract "Aspergillus oryzae O-1018 (FERM P-15834) separated from industrial koji for brewing sake was found to produce five papain-inhibitory compounds in the culture supernatant. The five isolated inhibitors were named CPI-1 to CPI-5, and their structures were elucidated by spectroscopic analyses and chemical degradation. We determined the structures of CPI-2, CPI-3 and CPI-4 as 4-amino-1-[[N- [(2S, 3S)-3-trans-carboxyoxiran-2-carbonyl]-L-isoleucyl] amino]butane, 5-amino-1-[[N-[(2S, 3S)-3-trans-carboxyoxiran-2-carbonyl]-L-isoleucyl]amino]pentane and N (8)- [N-[(2S, 3S)-3-trans-carboxyoxiran-2-carbonyl]-L-isoleu-cyl]spermidine, respectively. We also confirmed by a degradation experiment that CPI-1 consisted of L-trans-epoxysuccinic acid, L-tyrosine and spermidine, and that CPI-5 was composed of L-trans-epoxysuccinic acid, L-phenylalanine and spermidine. Although CPI-4 was identified as kojistatin A,(1)) the other CPIs seemed to be novel compounds. All CPIs were cysteine protease-specific inhibitors with appreciable selectivity toward cathepsin B and L. The inhibition potency of CPIs against cysteine proteases was as high as or higher than that of E-64. In particular, CPI-2, -3 and -4 were ten times more effective than E-64 toward cathepsin B and L, and CPI-1 and -5 were about 100 times more inhibitory than E-64 toward cathepsin L." @default.
• W2020184127 created "2016-06-24" @default.
• W2020184127 creator A5021059928 @default.
• W2020184127 creator A5032218494 @default.
• W2020184127 creator A5036403553 @default.
• W2020184127 creator A5055094851 @default.
• W2020184127 creator A5057757498 @default.
• W2020184127 creator A5071557055 @default.
• W2020184127 creator A5082349937 @default.
• W2020184127 creator A5085334038 @default.
• W2020184127 date "1998-01-01" @default.
• W2020184127 modified "2023-10-09" @default.
• W2020184127 title "Cysteine Protease Inhibitors Produced by the Industrial Koji Mold,<i>Aspergillus oryzae</i>O-1018" @default.
• W2020184127 cites W1574605835 @default.
• W2020184127 cites W1812339273 @default.
• W2020184127 cites W1967000705 @default.
• W2020184127 cites W1968640362 @default.
• W2020184127 cites W1969217703 @default.
• W2020184127 cites W1997035029 @default.
• W2020184127 cites W2017697235 @default.
• W2020184127 cites W2022117658 @default.
• W2020184127 cites W2027069366 @default.
• W2020184127 cites W2028031266 @default.
• W2020184127 cites W2034296548 @default.
• W2020184127 cites W2050953835 @default.
• W2020184127 cites W2071466064 @default.
• W2020184127 cites W2072694003 @default.
• W2020184127 cites W2076138386 @default.
• W2020184127 cites W2078441375 @default.
• W2020184127 cites W2079029280 @default.
• W2020184127 cites W2083124973 @default.
• W2020184127 cites W2126656466 @default.
• W2020184127 cites W2198105622 @default.
• W2020184127 cites W282147426 @default.
• W2020184127 cites W1972860802 @default.
• W2020184127 doi "https://doi.org/10.1271/bbb.62.907" @default.
• W2020184127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27392587" @default.
• W2020184127 hasPublicationYear "1998" @default.
• W2020184127 type Work @default.
• W2020184127 sameAs 2020184127 @default.
• W2020184127 citedByCount "13" @default.
• W2020184127 countsByYear W20201841272014 @default.
• W2020184127 countsByYear W20201841272018 @default.
• W2020184127 countsByYear W20201841272019 @default.
• W2020184127 countsByYear W20201841272020 @default.
• W2020184127 crossrefType "journal-article" @default.
• W2020184127 hasAuthorship W2020184127A5021059928 @default.
• W2020184127 hasAuthorship W2020184127A5032218494 @default.
• W2020184127 hasAuthorship W2020184127A5036403553 @default.
• W2020184127 hasAuthorship W2020184127A5055094851 @default.
• W2020184127 hasAuthorship W2020184127A5057757498 @default.
• W2020184127 hasAuthorship W2020184127A5071557055 @default.
• W2020184127 hasAuthorship W2020184127A5082349937 @default.
• W2020184127 hasAuthorship W2020184127A5085334038 @default.
• W2020184127 hasBestOaLocation W20201841271 @default.
• W2020184127 hasConcept C167844969 @default.
• W2020184127 hasConcept C181199279 @default.
• W2020184127 hasConcept C182220744 @default.
• W2020184127 hasConcept C185592680 @default.
• W2020184127 hasConcept C2776714187 @default.
• W2020184127 hasConcept C2777497464 @default.
• W2020184127 hasConcept C2779201268 @default.
• W2020184127 hasConcept C2779832904 @default.
• W2020184127 hasConcept C2780034444 @default.
• W2020184127 hasConcept C2781204770 @default.
• W2020184127 hasConcept C515207424 @default.
• W2020184127 hasConcept C55493867 @default.
• W2020184127 hasConcept C71240020 @default.
• W2020184127 hasConceptScore W2020184127C167844969 @default.
• W2020184127 hasConceptScore W2020184127C181199279 @default.
• W2020184127 hasConceptScore W2020184127C182220744 @default.
• W2020184127 hasConceptScore W2020184127C185592680 @default.
• W2020184127 hasConceptScore W2020184127C2776714187 @default.
• W2020184127 hasConceptScore W2020184127C2777497464 @default.
• W2020184127 hasConceptScore W2020184127C2779201268 @default.
• W2020184127 hasConceptScore W2020184127C2779832904 @default.
• W2020184127 hasConceptScore W2020184127C2780034444 @default.
• W2020184127 hasConceptScore W2020184127C2781204770 @default.
• W2020184127 hasConceptScore W2020184127C515207424 @default.
• W2020184127 hasConceptScore W2020184127C55493867 @default.
• W2020184127 hasConceptScore W2020184127C71240020 @default.
• W2020184127 hasIssue "5" @default.
• W2020184127 hasLocation W20201841271 @default.
• W2020184127 hasLocation W20201841272 @default.
• W2020184127 hasOpenAccess W2020184127 @default.
• W2020184127 hasPrimaryLocation W20201841271 @default.
• W2020184127 hasRelatedWork W1984164374 @default.
• W2020184127 hasRelatedWork W1999961572 @default.
• W2020184127 hasRelatedWork W2033993787 @default.
• W2020184127 hasRelatedWork W2072272548 @default.
• W2020184127 hasRelatedWork W2102008951 @default.
• W2020184127 hasRelatedWork W2138855398 @default.
• W2020184127 hasRelatedWork W2164827989 @default.
• W2020184127 hasRelatedWork W2944784906 @default.
• W2020184127 hasRelatedWork W4312447782 @default.
• W2020184127 hasRelatedWork W954505368 @default.
• W2020184127 hasVolume "62" @default.
• W2020184127 isParatext "false" @default.

• next