FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020185102> ?p ?o ?g. }

• W2020185102 endingPage "e29407" @default.
• W2020185102 startingPage "e29407" @default.
• W2020185102 abstract "Laboratory studies have suggested that antibiotic resistance may result in decreased fitness in the bacteria that harbor it. Observational studies have supported this, but due to ethical and practical considerations, it is rare to have experimental control over antibiotic prescription rates.We analyze data from a 54-month longitudinal trial that monitored pneumococcal drug resistance during and after biannual mass distribution of azithromycin for the elimination of the blinding eye disease, trachoma. Prescription of azithromycin and antibiotics that can create cross-resistance to it is rare in this part of the world. As a result, we were able to follow trends in resistance with minimal influence from unmeasured antibiotic use. Using these data, we fit a probabilistic disease transmission model that included two resistant strains, corresponding to the two dominant modes of resistance to macrolide antibiotics. We estimated the relative fitness of these two strains to be 0.86 (95% CI 0.80 to 0.90), and 0.88 (95% CI 0.82 to 0.93), relative to antibiotic-sensitive strains. We then used these estimates to predict that, within 5 years of the last antibiotic treatment, there would be a 95% chance of elimination of macrolide resistance by intra-species competition alone.Although it is quite possible that the fitness cost of macrolide resistance is sufficient to ensure its eventual elimination in the absence of antibiotic selection, this process takes time, and prevention is likely the best policy in the fight against resistance." @default.
• W2020185102 created "2016-06-24" @default.
• W2020185102 creator A5021420755 @default.
• W2020185102 creator A5028808282 @default.
• W2020185102 creator A5031739654 @default.
• W2020185102 creator A5056077950 @default.
• W2020185102 creator A5069369290 @default.
• W2020185102 creator A5075952432 @default.
• W2020185102 creator A5080095497 @default.
• W2020185102 creator A5083977951 @default.
• W2020185102 creator A5087429515 @default.
• W2020185102 date "2012-01-17" @default.
• W2020185102 modified "2023-10-01" @default.
• W2020185102 title "The Fitness Cost of Antibiotic Resistance in Streptococcus pneumoniae: Insight from the Field" @default.
• W2020185102 cites W1670828833 @default.
• W2020185102 cites W1922732464 @default.
• W2020185102 cites W1977685479 @default.
• W2020185102 cites W1978653163 @default.
• W2020185102 cites W1982556454 @default.
• W2020185102 cites W2015856931 @default.
• W2020185102 cites W2038678671 @default.
• W2020185102 cites W2043887558 @default.
• W2020185102 cites W2055782637 @default.
• W2020185102 cites W2071110718 @default.
• W2020185102 cites W2073409360 @default.
• W2020185102 cites W2073556554 @default.
• W2020185102 cites W2077548148 @default.
• W2020185102 cites W2081816876 @default.
• W2020185102 cites W2086827484 @default.
• W2020185102 cites W2100382637 @default.
• W2020185102 cites W2101232275 @default.
• W2020185102 cites W2107860452 @default.
• W2020185102 cites W2111614444 @default.
• W2020185102 cites W2120644156 @default.
• W2020185102 cites W2128194846 @default.
• W2020185102 cites W2130893340 @default.
• W2020185102 cites W2134936973 @default.
• W2020185102 cites W2138607660 @default.
• W2020185102 cites W2141405726 @default.
• W2020185102 cites W2143391752 @default.
• W2020185102 cites W2146799886 @default.
• W2020185102 cites W2166597151 @default.
• W2020185102 cites W2171726487 @default.
• W2020185102 doi "https://doi.org/10.1371/journal.pone.0029407" @default.
• W2020185102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3260144" @default.
• W2020185102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22272234" @default.
• W2020185102 hasPublicationYear "2012" @default.
• W2020185102 type Work @default.
• W2020185102 sameAs 2020185102 @default.
• W2020185102 citedByCount "44" @default.
• W2020185102 countsByYear W20201851022012 @default.
• W2020185102 countsByYear W20201851022013 @default.
• W2020185102 countsByYear W20201851022015 @default.
• W2020185102 countsByYear W20201851022016 @default.
• W2020185102 countsByYear W20201851022017 @default.
• W2020185102 countsByYear W20201851022018 @default.
• W2020185102 countsByYear W20201851022019 @default.
• W2020185102 countsByYear W20201851022020 @default.
• W2020185102 countsByYear W20201851022021 @default.
• W2020185102 countsByYear W20201851022022 @default.
• W2020185102 countsByYear W20201851022023 @default.
• W2020185102 crossrefType "journal-article" @default.
• W2020185102 hasAuthorship W2020185102A5021420755 @default.
• W2020185102 hasAuthorship W2020185102A5028808282 @default.
• W2020185102 hasAuthorship W2020185102A5031739654 @default.
• W2020185102 hasAuthorship W2020185102A5056077950 @default.
• W2020185102 hasAuthorship W2020185102A5069369290 @default.
• W2020185102 hasAuthorship W2020185102A5075952432 @default.
• W2020185102 hasAuthorship W2020185102A5080095497 @default.
• W2020185102 hasAuthorship W2020185102A5083977951 @default.
• W2020185102 hasAuthorship W2020185102A5087429515 @default.
• W2020185102 hasBestOaLocation W20201851021 @default.
• W2020185102 hasConcept C114851261 @default.
• W2020185102 hasConcept C2426938 @default.
• W2020185102 hasConcept C2778907293 @default.
• W2020185102 hasConcept C2781253189 @default.
• W2020185102 hasConcept C501593827 @default.
• W2020185102 hasConcept C71924100 @default.
• W2020185102 hasConcept C86803240 @default.
• W2020185102 hasConcept C89423630 @default.
• W2020185102 hasConcept C94665300 @default.
• W2020185102 hasConcept C98274493 @default.
• W2020185102 hasConceptScore W2020185102C114851261 @default.
• W2020185102 hasConceptScore W2020185102C2426938 @default.
• W2020185102 hasConceptScore W2020185102C2778907293 @default.
• W2020185102 hasConceptScore W2020185102C2781253189 @default.
• W2020185102 hasConceptScore W2020185102C501593827 @default.
• W2020185102 hasConceptScore W2020185102C71924100 @default.
• W2020185102 hasConceptScore W2020185102C86803240 @default.
• W2020185102 hasConceptScore W2020185102C89423630 @default.
• W2020185102 hasConceptScore W2020185102C94665300 @default.
• W2020185102 hasConceptScore W2020185102C98274493 @default.
• W2020185102 hasIssue "1" @default.
• W2020185102 hasLocation W20201851021 @default.
• W2020185102 hasLocation W20201851022 @default.
• W2020185102 hasLocation W20201851023 @default.
• W2020185102 hasLocation W20201851024 @default.
• W2020185102 hasLocation W20201851025 @default.

• next