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- W2020185269 abstract "Myelodysplastic syndrome (MDS) is a frustrating disorder which until recently lacked effective treatment. Patients usually succumb to infection, bleeding complications, and/or progression to acute leukemia. Recombinant cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte (G) CSF, interleukin (IL) 3 and erythropoietin (Epo), have now been used to ameliorate the cytopenias associated with this disease. Small clinical trials in MDS patients using cytokines with myeloid activity (G-CSF, GM-CSF, IL-3) have shown consistent elevations in the WBC counts with little success in elevating hemoglobin or platelets. Epo is able to increase the hemoglobin in a small group of MDS patients. Future trials utilizing combinations of these cytokines may lead to multilineage effects." @default.
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- W2020185269 date "1991-05-01" @default.
- W2020185269 modified "2023-09-26" @default.
- W2020185269 title "Clinical use of cytokines in the treatment of myelodysplastic syndrome (MDS): A review" @default.
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- W2020185269 doi "https://doi.org/10.1002/stem.5530090706" @default.
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