Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020187231> ?p ?o ?g. }
- W2020187231 abstract "Transforming growth factor alpha (TGF alpha) induces dose- and time-dependent stimulation of prostacyclin (PGI2) production by cultured human umbilical vein endothelial cells. The lowest stimulatory concentration of TGF alpha was 0.1 ng/ml and the maximal response, a 2.7-fold rise, was obtained with 10 ng/ml. The stimulation, which lasted at least 24 h, was blocked by cycloheximide and by indomethacin. TGF alpha induced PGI2 production at 10-100 times lower concentrations than did epidermal growth factor (EGF), although in stimulating endothelial cell growth the two factors were equipotent. This is the first demonstration that TGF alpha enhances PGI2 production by human cells. Moreover, this is the first evidence that it acts as both an agonist (growth) and a superagonist (PGI2 production) of EGF in the same cell type. I suggest that this phenomenon may be involved with the angiogenic activity of TGF alpha." @default.
- W2020187231 created "2016-06-24" @default.
- W2020187231 creator A5049950699 @default.
- W2020187231 date "1989-05-01" @default.
- W2020187231 modified "2023-10-17" @default.
- W2020187231 title "Transforming growth factor α stimulates prostacyclin production by cultured human vascular endothelial cells more potently than epidermal growth factor" @default.
- W2020187231 cites W146757783 @default.
- W2020187231 cites W1572362848 @default.
- W2020187231 cites W1627068912 @default.
- W2020187231 cites W1867003241 @default.
- W2020187231 cites W1970516412 @default.
- W2020187231 cites W1989675296 @default.
- W2020187231 cites W2024071649 @default.
- W2020187231 cites W2024187885 @default.
- W2020187231 cites W2024507604 @default.
- W2020187231 cites W2031421855 @default.
- W2020187231 cites W2038206190 @default.
- W2020187231 cites W2045649069 @default.
- W2020187231 cites W2054012934 @default.
- W2020187231 cites W2065418754 @default.
- W2020187231 cites W2065710903 @default.
- W2020187231 cites W2072408832 @default.
- W2020187231 cites W2088467882 @default.
- W2020187231 cites W2095549623 @default.
- W2020187231 cites W2129736939 @default.
- W2020187231 cites W2155958456 @default.
- W2020187231 cites W2157603347 @default.
- W2020187231 cites W2163100568 @default.
- W2020187231 cites W2258382192 @default.
- W2020187231 cites W2270149052 @default.
- W2020187231 cites W2437604087 @default.
- W2020187231 doi "https://doi.org/10.1016/s0006-291x(89)80116-0" @default.
- W2020187231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2658990" @default.
- W2020187231 hasPublicationYear "1989" @default.
- W2020187231 type Work @default.
- W2020187231 sameAs 2020187231 @default.
- W2020187231 citedByCount "23" @default.
- W2020187231 crossrefType "journal-article" @default.
- W2020187231 hasAuthorship W2020187231A5049950699 @default.
- W2020187231 hasConcept C118131993 @default.
- W2020187231 hasConcept C123012128 @default.
- W2020187231 hasConcept C125555471 @default.
- W2020187231 hasConcept C126322002 @default.
- W2020187231 hasConcept C134018914 @default.
- W2020187231 hasConcept C159110408 @default.
- W2020187231 hasConcept C170493617 @default.
- W2020187231 hasConcept C185592680 @default.
- W2020187231 hasConcept C202751555 @default.
- W2020187231 hasConcept C24998067 @default.
- W2020187231 hasConcept C2775944032 @default.
- W2020187231 hasConcept C2775960820 @default.
- W2020187231 hasConcept C2776362946 @default.
- W2020187231 hasConcept C2777411675 @default.
- W2020187231 hasConcept C2778128677 @default.
- W2020187231 hasConcept C2781128415 @default.
- W2020187231 hasConcept C49453240 @default.
- W2020187231 hasConcept C54355233 @default.
- W2020187231 hasConcept C55493867 @default.
- W2020187231 hasConcept C64943373 @default.
- W2020187231 hasConcept C71924100 @default.
- W2020187231 hasConcept C81885089 @default.
- W2020187231 hasConcept C86803240 @default.
- W2020187231 hasConceptScore W2020187231C118131993 @default.
- W2020187231 hasConceptScore W2020187231C123012128 @default.
- W2020187231 hasConceptScore W2020187231C125555471 @default.
- W2020187231 hasConceptScore W2020187231C126322002 @default.
- W2020187231 hasConceptScore W2020187231C134018914 @default.
- W2020187231 hasConceptScore W2020187231C159110408 @default.
- W2020187231 hasConceptScore W2020187231C170493617 @default.
- W2020187231 hasConceptScore W2020187231C185592680 @default.
- W2020187231 hasConceptScore W2020187231C202751555 @default.
- W2020187231 hasConceptScore W2020187231C24998067 @default.
- W2020187231 hasConceptScore W2020187231C2775944032 @default.
- W2020187231 hasConceptScore W2020187231C2775960820 @default.
- W2020187231 hasConceptScore W2020187231C2776362946 @default.
- W2020187231 hasConceptScore W2020187231C2777411675 @default.
- W2020187231 hasConceptScore W2020187231C2778128677 @default.
- W2020187231 hasConceptScore W2020187231C2781128415 @default.
- W2020187231 hasConceptScore W2020187231C49453240 @default.
- W2020187231 hasConceptScore W2020187231C54355233 @default.
- W2020187231 hasConceptScore W2020187231C55493867 @default.
- W2020187231 hasConceptScore W2020187231C64943373 @default.
- W2020187231 hasConceptScore W2020187231C71924100 @default.
- W2020187231 hasConceptScore W2020187231C81885089 @default.
- W2020187231 hasConceptScore W2020187231C86803240 @default.
- W2020187231 hasLocation W20201872311 @default.
- W2020187231 hasLocation W20201872312 @default.
- W2020187231 hasOpenAccess W2020187231 @default.
- W2020187231 hasPrimaryLocation W20201872311 @default.
- W2020187231 hasRelatedWork W1983738670 @default.
- W2020187231 hasRelatedWork W1998340779 @default.
- W2020187231 hasRelatedWork W1999660566 @default.
- W2020187231 hasRelatedWork W2020187231 @default.
- W2020187231 hasRelatedWork W2036315926 @default.
- W2020187231 hasRelatedWork W2133171417 @default.
- W2020187231 hasRelatedWork W2144562624 @default.
- W2020187231 hasRelatedWork W2171223757 @default.
- W2020187231 hasRelatedWork W2437604087 @default.
- W2020187231 hasRelatedWork W1995193459 @default.
- W2020187231 isParatext "false" @default.