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- W2020187356 abstract "The extracellular matrix protein 1 (ECM1) is expressed around blood vessels, which suggest a role for ECM1 in angiogenesis. Recombinant ECM1 stimulates proliferation of cultured endothelial cells and promotes blood vessel formation in the chorioallantoic membrane of chicken embryos. These observations make ECM1 a possible trigger for angiogenesis, tumor progression and malignancies. Interaction of ECM1 with perlecan, MMP-9 and fibulin-1C/D contributes to this hypothesis. However, the importance of ECM1 in cancer biology has been neglected so far. Nevertheless, a survey of ECM1 expression in different tumors indicated that ECM1, although not tumor specific, is significantly elevated in many malignant epithelial tumors that give rise to metastases, emphasizing its relevance in the cancer process." @default.
- W2020187356 created "2016-06-24" @default.
- W2020187356 creator A5024663273 @default.
- W2020187356 creator A5051163835 @default.
- W2020187356 creator A5091381092 @default.
- W2020187356 date "2008-01-01" @default.
- W2020187356 modified "2023-10-05" @default.
- W2020187356 title "The Extracellular Matrix Protein 1: Its Molecular Interaction and Implication in Tumor Progression" @default.
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- W2020187356 doi "https://doi.org/10.1080/07357900701788148" @default.
- W2020187356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18443958" @default.
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