FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020191191> ?p ?o ?g. }

• W2020191191 endingPage "5723" @default.
• W2020191191 startingPage "5718" @default.
• W2020191191 abstract "Cystic fibrosis (CF) is an autosomal recessive disorder, the most common lethal genetic disease in Caucasians. Respiratory disease is the major cause of morbidity and mortality. Indeed, 95% of CF patients die of respiratory failure. Pseudomonas aeruginosa , an opportunistic pathogen, chronically infects the lungs of over 85% of CF patients. It is ineradicable by antibiotics and responsible for airway mucus overproduction that contributes to airway obstruction and death. The molecular mechanisms underlying this pathology are unknown. Here we show that P. aeruginosa activates a c-Src-Ras-MEK1/2-MAPK-pp90rsk signaling pathway that leads to activation of nuclear factor NF-κB (p65/p50). Activated NF-κB binds to a κB site in the 5′-flanking region of the MUC2 gene and activates MUC2 mucin transcription. These studies bring new insight into bacterial–epithelial interactions and more specifically into the molecular pathogenesis of cystic fibrosis. Understanding these signaling and gene regulatory mechanisms opens up new therapeutic targets for cystic fibrosis." @default.
• W2020191191 created "2016-06-24" @default.
• W2020191191 creator A5013542315 @default.
• W2020191191 creator A5017039946 @default.
• W2020191191 creator A5033029404 @default.
• W2020191191 creator A5053736472 @default.
• W2020191191 creator A5057614334 @default.
• W2020191191 creator A5064765788 @default.
• W2020191191 creator A5066048441 @default.
• W2020191191 date "1998-05-12" @default.
• W2020191191 modified "2023-10-05" @default.
• W2020191191 title "Activation of NF-κB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for <i>Pseudomonas aeruginosa</i> -induced mucin overproduction in epithelial cells" @default.
• W2020191191 cites W1559196053 @default.
• W2020191191 cites W1562448272 @default.
• W2020191191 cites W1566502635 @default.
• W2020191191 cites W1795897263 @default.
• W2020191191 cites W1822061653 @default.
• W2020191191 cites W1835109348 @default.
• W2020191191 cites W1973341558 @default.
• W2020191191 cites W1976999762 @default.
• W2020191191 cites W1978798502 @default.
• W2020191191 cites W1979520552 @default.
• W2020191191 cites W1988409513 @default.
• W2020191191 cites W2001767364 @default.
• W2020191191 cites W2031452885 @default.
• W2020191191 cites W2035088045 @default.
• W2020191191 cites W2035936653 @default.
• W2020191191 cites W2040470926 @default.
• W2020191191 cites W2055181868 @default.
• W2020191191 cites W2066671615 @default.
• W2020191191 cites W2069104210 @default.
• W2020191191 cites W2070023258 @default.
• W2020191191 cites W2080797320 @default.
• W2020191191 cites W2088587327 @default.
• W2020191191 cites W2090895449 @default.
• W2020191191 cites W2095152292 @default.
• W2020191191 cites W2129644762 @default.
• W2020191191 cites W2134912543 @default.
• W2020191191 cites W2147286631 @default.
• W2020191191 cites W2151489147 @default.
• W2020191191 cites W2166781237 @default.
• W2020191191 cites W2399658171 @default.
• W2020191191 doi "https://doi.org/10.1073/pnas.95.10.5718" @default.
• W2020191191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/20445" @default.
• W2020191191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9576950" @default.
• W2020191191 hasPublicationYear "1998" @default.
• W2020191191 type Work @default.
• W2020191191 sameAs 2020191191 @default.
• W2020191191 citedByCount "328" @default.
• W2020191191 countsByYear W20201911912012 @default.
• W2020191191 countsByYear W20201911912013 @default.
• W2020191191 countsByYear W20201911912014 @default.
• W2020191191 countsByYear W20201911912015 @default.
• W2020191191 countsByYear W20201911912016 @default.
• W2020191191 countsByYear W20201911912017 @default.
• W2020191191 countsByYear W20201911912018 @default.
• W2020191191 countsByYear W20201911912019 @default.
• W2020191191 countsByYear W20201911912020 @default.
• W2020191191 countsByYear W20201911912021 @default.
• W2020191191 countsByYear W20201911912022 @default.
• W2020191191 countsByYear W20201911912023 @default.
• W2020191191 crossrefType "journal-article" @default.
• W2020191191 hasAuthorship W2020191191A5013542315 @default.
• W2020191191 hasAuthorship W2020191191A5017039946 @default.
• W2020191191 hasAuthorship W2020191191A5033029404 @default.
• W2020191191 hasAuthorship W2020191191A5053736472 @default.
• W2020191191 hasAuthorship W2020191191A5057614334 @default.
• W2020191191 hasAuthorship W2020191191A5064765788 @default.
• W2020191191 hasAuthorship W2020191191A5066048441 @default.
• W2020191191 hasBestOaLocation W20201911911 @default.
• W2020191191 hasConcept C104317684 @default.
• W2020191191 hasConcept C179264091 @default.
• W2020191191 hasConcept C18903297 @default.
• W2020191191 hasConcept C203014093 @default.
• W2020191191 hasConcept C2776938444 @default.
• W2020191191 hasConcept C2777312293 @default.
• W2020191191 hasConcept C2777637488 @default.
• W2020191191 hasConcept C2780942790 @default.
• W2020191191 hasConcept C502942594 @default.
• W2020191191 hasConcept C523546767 @default.
• W2020191191 hasConcept C54355233 @default.
• W2020191191 hasConcept C55493867 @default.
• W2020191191 hasConcept C57074206 @default.
• W2020191191 hasConcept C62478195 @default.
• W2020191191 hasConcept C86339819 @default.
• W2020191191 hasConcept C86803240 @default.
• W2020191191 hasConcept C95444343 @default.
• W2020191191 hasConceptScore W2020191191C104317684 @default.
• W2020191191 hasConceptScore W2020191191C179264091 @default.
• W2020191191 hasConceptScore W2020191191C18903297 @default.
• W2020191191 hasConceptScore W2020191191C203014093 @default.
• W2020191191 hasConceptScore W2020191191C2776938444 @default.
• W2020191191 hasConceptScore W2020191191C2777312293 @default.
• W2020191191 hasConceptScore W2020191191C2777637488 @default.
• W2020191191 hasConceptScore W2020191191C2780942790 @default.
• W2020191191 hasConceptScore W2020191191C502942594 @default.
• W2020191191 hasConceptScore W2020191191C523546767 @default.
• W2020191191 hasConceptScore W2020191191C54355233 @default.

• next