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- W2020194502 abstract "Milrinone is a positive inotrope/vasodilator that inhibits cardiovascular low Km cAMP phosphodiesterase (PDE) and not Na+−K+ ATPase activity. To explore other possible mechanisms of action, we quantitated the effects of milrinone on Ca2+-stimulated Mg2+ ATPase activity in guinea pig aortic smooth muscle plasma membranes. Milrinone inhibited Ca2+- stimulated activity, but not basal activity, in aortic microsomes. Maximum inhibition (70%) occurred at 1 μM, which coincided with the inflection of a parabolic dose-response curve. In a sarcolemmal-enriched (F1) aortic preparation, 1 μM cAMP, 1 μM Cl-930 (another low Km cAMP PDE inhibitor), and 100 μM W-7 (a calmodulin antagonist) all inhibited Ca2 -stimulated Mg2+ ATPase activity. This F1 preparation contained cAMP PDE activity which was inhibited by 1 μM milrinone (26%) and 1 μM Cl-930 (40%) but not by 100 μM W-7. The inhibition of F1 Ca2+ -Mg2+ ATPase activity by 1 μM milrinone could be diminished by increasing the concentration of CaCl2 in reaction mixtures. In sum, these studies show that milrinone can inhibit vascular sarcolemmal Ca2+ -stimulated Mg2+ ATPase activity. However, inhibition may be direct or direct or may be secondary to cAMP PDE inhibition in vascular sarcolemma, since inhibition also occurs with cAMP and another low-Km cAMP PDE inhibitor, Cl-930." @default.
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- W2020194502 title "Inhibition of guinea pig aortic sarcolemmal Ca2+-Mg2+ ATPase and cAMP phosphodiesterase activity by milrinone" @default.
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- W2020194502 doi "https://doi.org/10.1002/ddr.430190408" @default.
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