Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020197804> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2020197804 endingPage "91" @default.
- W2020197804 startingPage "83" @default.
- W2020197804 abstract "Beta(3)-adrenergic receptors have been reported to function primarily in adipose tissues to regulate thermogenesis. In this study, we determined if beta-adrenergic receptors are present on human choroidal endothelial cells and examined their ability to promote invasion, proliferation, and/or cell elongation. Using western blotting techniques and assays of cell invasion, cell proliferation, and endothelial cell elongation, we were able to determine that human choroidal endothelial cells do possess all three subtypes of beta-adrenergic receptors. Stimulation of the beta(3)-adrenergic receptor with BRL37344, a specific beta(3)-adrenergic receptor agonist, resulted in phosphorylation of Src, Akt, and ERK1/2. BRL37344 treatment also increased choroidal endothelial cell invasion by 103% above control values; the invasion response was inhibited by PP2 (Src inhibitor), LY294002 (PI3K inhibitor), Akt inhibitor (Akt-I), and matrix metalloproteinase 2/9 inhibitor (MMP-I). Invasion was not affected by PD98059 (mek inhibitor) or KT5823 (protein kinase G inhibitor). BRL37344 produced a significant increase in the total elongation of choroidal endothelial cells formed on Matrigel over a 24hr period. BRL37344 did significantly increase proliferation, although not to the same level as invasion. Stimulation of choroidal endothelial cells with dobutamine to activate beta(1)/beta(2)-adrenergic receptors did not affect invasion, proliferation, or endothelial cell elongation. In conclusion, beta(3)-adrenergic receptors may play a role in choroidal endothelial cell invasion and elongation, while playing a more limited function in regulation of cell proliferation." @default.
- W2020197804 created "2016-06-24" @default.
- W2020197804 creator A5007631801 @default.
- W2020197804 creator A5051180440 @default.
- W2020197804 creator A5054565442 @default.
- W2020197804 creator A5067781437 @default.
- W2020197804 date "2005-01-01" @default.
- W2020197804 modified "2023-10-05" @default.
- W2020197804 title "β3-Adrenergic receptors mediate choroidal endothelial cell invasion, proliferation, and cell elongation" @default.
- W2020197804 cites W146083735 @default.
- W2020197804 cites W1979983164 @default.
- W2020197804 cites W1993530603 @default.
- W2020197804 cites W1998217029 @default.
- W2020197804 cites W2000871573 @default.
- W2020197804 cites W2039668396 @default.
- W2020197804 cites W2042113277 @default.
- W2020197804 cites W2050726791 @default.
- W2020197804 cites W2057334352 @default.
- W2020197804 cites W2117821842 @default.
- W2020197804 cites W2130156356 @default.
- W2020197804 cites W2158336844 @default.
- W2020197804 cites W2911662087 @default.
- W2020197804 cites W4243709691 @default.
- W2020197804 doi "https://doi.org/10.1016/j.exer.2004.08.015" @default.
- W2020197804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15652529" @default.
- W2020197804 hasPublicationYear "2005" @default.
- W2020197804 type Work @default.
- W2020197804 sameAs 2020197804 @default.
- W2020197804 citedByCount "37" @default.
- W2020197804 countsByYear W20201978042013 @default.
- W2020197804 countsByYear W20201978042014 @default.
- W2020197804 countsByYear W20201978042016 @default.
- W2020197804 countsByYear W20201978042017 @default.
- W2020197804 countsByYear W20201978042018 @default.
- W2020197804 countsByYear W20201978042019 @default.
- W2020197804 countsByYear W20201978042020 @default.
- W2020197804 countsByYear W20201978042021 @default.
- W2020197804 countsByYear W20201978042022 @default.
- W2020197804 countsByYear W20201978042023 @default.
- W2020197804 crossrefType "journal-article" @default.
- W2020197804 hasAuthorship W2020197804A5007631801 @default.
- W2020197804 hasAuthorship W2020197804A5051180440 @default.
- W2020197804 hasAuthorship W2020197804A5054565442 @default.
- W2020197804 hasAuthorship W2020197804A5067781437 @default.
- W2020197804 hasConcept C123012128 @default.
- W2020197804 hasConcept C126322002 @default.
- W2020197804 hasConcept C134018914 @default.
- W2020197804 hasConcept C1491633281 @default.
- W2020197804 hasConcept C170493617 @default.
- W2020197804 hasConcept C202751555 @default.
- W2020197804 hasConcept C2778608917 @default.
- W2020197804 hasConcept C55493867 @default.
- W2020197804 hasConcept C62112901 @default.
- W2020197804 hasConcept C62478195 @default.
- W2020197804 hasConcept C71924100 @default.
- W2020197804 hasConcept C75217442 @default.
- W2020197804 hasConcept C86803240 @default.
- W2020197804 hasConcept C95444343 @default.
- W2020197804 hasConceptScore W2020197804C123012128 @default.
- W2020197804 hasConceptScore W2020197804C126322002 @default.
- W2020197804 hasConceptScore W2020197804C134018914 @default.
- W2020197804 hasConceptScore W2020197804C1491633281 @default.
- W2020197804 hasConceptScore W2020197804C170493617 @default.
- W2020197804 hasConceptScore W2020197804C202751555 @default.
- W2020197804 hasConceptScore W2020197804C2778608917 @default.
- W2020197804 hasConceptScore W2020197804C55493867 @default.
- W2020197804 hasConceptScore W2020197804C62112901 @default.
- W2020197804 hasConceptScore W2020197804C62478195 @default.
- W2020197804 hasConceptScore W2020197804C71924100 @default.
- W2020197804 hasConceptScore W2020197804C75217442 @default.
- W2020197804 hasConceptScore W2020197804C86803240 @default.
- W2020197804 hasConceptScore W2020197804C95444343 @default.
- W2020197804 hasIssue "1" @default.
- W2020197804 hasLocation W20201978041 @default.
- W2020197804 hasLocation W20201978042 @default.
- W2020197804 hasOpenAccess W2020197804 @default.
- W2020197804 hasPrimaryLocation W20201978041 @default.
- W2020197804 hasRelatedWork W1996846474 @default.
- W2020197804 hasRelatedWork W2018368842 @default.
- W2020197804 hasRelatedWork W2033472167 @default.
- W2020197804 hasRelatedWork W2034583712 @default.
- W2020197804 hasRelatedWork W2052453588 @default.
- W2020197804 hasRelatedWork W2061429094 @default.
- W2020197804 hasRelatedWork W2063619316 @default.
- W2020197804 hasRelatedWork W2083693850 @default.
- W2020197804 hasRelatedWork W2169225653 @default.
- W2020197804 hasRelatedWork W2414846389 @default.
- W2020197804 hasVolume "80" @default.
- W2020197804 isParatext "false" @default.
- W2020197804 isRetracted "false" @default.
- W2020197804 magId "2020197804" @default.
- W2020197804 workType "article" @default.