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• W2020198633 abstract "The SAR of capsazepine revealed that tetrahydroisoquinoline (TIQ) moiety is a core pharmacophore of TRPV1 activity. This implied that conjugates of endogenous TIQs with fatty acids would be active at TRPV1 receptors. Six such compounds were synthesized and tested for calcium mobilization at recombinant TRPV1 receptors overexpressed in HEK293 cells. Three compounds showed partial TRPV1 agonism with EC50 values in the low micromolar range and maximal efficacies between 25% and 55% of capsaicin." @default.
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• W2020198633 date "2007-09-01" @default.
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• W2020198633 title "Fatty acyl amides of endogenous tetrahydroisoquinolines are active at the recombinant human TRPV1 receptor" @default.
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• W2020198633 doi "https://doi.org/10.1016/j.bmc.2007.06.032" @default.
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