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• W2020199093 abstract "<i>Background:</i> Peak oxygen uptake (peak V<i>O</i>₂) is a predictor of outcome in patients with lung disease. In these patients, peak V<i>O</i>₂ is typically determined by ventilation and gas exchange. However, it is not well known whether cardiac strain contributes to peak V<i>O</i>₂ in patients with chronic lung disease. <i>Objective:</i> To assess the relationship between several novel biomarkers reflecting different aspects of cardiac function and peak V<i>O</i>₂ in patients with chronic lung disease. <i>Methods:</i> Plasma concentrations of midregional pro-A-type natriuret- ic peptide (MR-proANP), midregional proadrenomedullin (MR-proADM), C-terminal proendothelin-1 (CT-proET-1), and C-terminal provasopressin (copeptin) were measured in 85 patients with a variety of chronic pulmonary diseases [age 57 ± 14 years, forced expiratory volume in the 1st second (FEV₁) 76 ± 23% of the predicted value] undergoing maximal cardiopulmonary exercise testing (peak V<i>O</i>₂ 18.6 ± 6.6 ml/kg/min). <i>Results:</i> Raised MR-proANP (r = –0.54), MR- proADM (r = –0.54), and CT-proET-1 (r = –0.49; p < 0.001 for all) but not copeptin (r = –0.05; p = 0.68) concentrations were associated with lower peak V<i>O</i>₂, and these associations were independent of age, gender, medication, FEV₁ and oxygenation. The relationship between MR-proANP, MR-proADM, and CT-proET-1 and peak V<i>O</i>₂ was significant whether patients had an obstructive ventilatory disease or not. <i>Conclusions:</i> In patients with chronic lung disease, several biomarkers known to reflect measures of cardiac function were associated with peak V<i>O</i>₂ independent of lung function, indicating that cardiac strain may contribute to exercise limitation in these patients due to concomitant cardiac disease or in the context of a pulmonary-cardiac interaction." @default.
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• W2020199093 date "2010-01-01" @default.
• W2020199093 modified "2023-10-18" @default.
• W2020199093 title "Biomarkers and Peak Oxygen Uptake in Patients with Chronic Lung Disease" @default.
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• W2020199093 doi "https://doi.org/10.1159/000319038" @default.
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