Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020202471> ?p ?o ?g. }
- W2020202471 endingPage "6793" @default.
- W2020202471 startingPage "6783" @default.
- W2020202471 abstract "The chromosomal passenger complex (CPC) has been identified as a master regulator of mitosis. In particular, proper chromosome segregation and cytokinesis depend on the correct localization and function of the CPC. Within the complex, the kinase Aurora B associates with Incenp, Survivin, and Borealin. The stoichiometry of the complex as well as a complete understanding of how these four components interact with each other remains to be elucidated. Here, we identify a new domain of Borealin. We determined its structure using NMR spectroscopy and discovered a novel dimerization motif. Interestingly, we found that substitutions at Borealin T230, recently identified as an Mps1 phosphorylation site, can modulate the dimerization state of Borealin. Mutation of this single residue to alanine or valine impairs Aurora B activity during mitosis and causes chromosome segregation defects. This study reveals that Mps1 regulates the CPC through a novel Borealin domain." @default.
- W2020202471 created "2016-06-24" @default.
- W2020202471 creator A5044566453 @default.
- W2020202471 creator A5061261743 @default.
- W2020202471 creator A5065103844 @default.
- W2020202471 creator A5066867788 @default.
- W2020202471 creator A5075725880 @default.
- W2020202471 date "2009-07-01" @default.
- W2020202471 modified "2023-09-25" @default.
- W2020202471 title "Phosphorylation of a Borealin Dimerization Domain Is Required for Proper Chromosome Segregation" @default.
- W2020202471 cites W1589295940 @default.
- W2020202471 cites W1967969318 @default.
- W2020202471 cites W1970445062 @default.
- W2020202471 cites W1971707621 @default.
- W2020202471 cites W1975459052 @default.
- W2020202471 cites W1977922844 @default.
- W2020202471 cites W1982384929 @default.
- W2020202471 cites W1985133799 @default.
- W2020202471 cites W1992013168 @default.
- W2020202471 cites W1995017064 @default.
- W2020202471 cites W2002125670 @default.
- W2020202471 cites W2002195659 @default.
- W2020202471 cites W2003729867 @default.
- W2020202471 cites W2007931030 @default.
- W2020202471 cites W2042231416 @default.
- W2020202471 cites W2048938594 @default.
- W2020202471 cites W2069743555 @default.
- W2020202471 cites W2072035559 @default.
- W2020202471 cites W2078394309 @default.
- W2020202471 cites W2088309079 @default.
- W2020202471 cites W2093968495 @default.
- W2020202471 cites W2098082668 @default.
- W2020202471 cites W2099324589 @default.
- W2020202471 cites W2108688550 @default.
- W2020202471 cites W2111428927 @default.
- W2020202471 cites W2114705132 @default.
- W2020202471 cites W2114918924 @default.
- W2020202471 cites W2119034696 @default.
- W2020202471 cites W2124785173 @default.
- W2020202471 cites W2125754609 @default.
- W2020202471 cites W2128466431 @default.
- W2020202471 cites W2129551171 @default.
- W2020202471 cites W2135338948 @default.
- W2020202471 cites W2139059053 @default.
- W2020202471 cites W2143519602 @default.
- W2020202471 cites W2144998676 @default.
- W2020202471 cites W2145009672 @default.
- W2020202471 cites W2148807789 @default.
- W2020202471 cites W2149435871 @default.
- W2020202471 cites W2154809041 @default.
- W2020202471 cites W2155660862 @default.
- W2020202471 cites W2166102124 @default.
- W2020202471 cites W2168696636 @default.
- W2020202471 cites W2168881161 @default.
- W2020202471 cites W2169707043 @default.
- W2020202471 cites W2169821755 @default.
- W2020202471 cites W4243546559 @default.
- W2020202471 doi "https://doi.org/10.1021/bi900530v" @default.
- W2020202471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19530738" @default.
- W2020202471 hasPublicationYear "2009" @default.
- W2020202471 type Work @default.
- W2020202471 sameAs 2020202471 @default.
- W2020202471 citedByCount "40" @default.
- W2020202471 countsByYear W20202024712012 @default.
- W2020202471 countsByYear W20202024712015 @default.
- W2020202471 countsByYear W20202024712016 @default.
- W2020202471 countsByYear W20202024712017 @default.
- W2020202471 countsByYear W20202024712018 @default.
- W2020202471 countsByYear W20202024712019 @default.
- W2020202471 countsByYear W20202024712020 @default.
- W2020202471 countsByYear W20202024712021 @default.
- W2020202471 countsByYear W20202024712022 @default.
- W2020202471 countsByYear W20202024712023 @default.
- W2020202471 crossrefType "journal-article" @default.
- W2020202471 hasAuthorship W2020202471A5044566453 @default.
- W2020202471 hasAuthorship W2020202471A5061261743 @default.
- W2020202471 hasAuthorship W2020202471A5065103844 @default.
- W2020202471 hasAuthorship W2020202471A5066867788 @default.
- W2020202471 hasAuthorship W2020202471A5075725880 @default.
- W2020202471 hasConcept C104317684 @default.
- W2020202471 hasConcept C141937037 @default.
- W2020202471 hasConcept C1491633281 @default.
- W2020202471 hasConcept C2778354886 @default.
- W2020202471 hasConcept C30481170 @default.
- W2020202471 hasConcept C45472230 @default.
- W2020202471 hasConcept C54355233 @default.
- W2020202471 hasConcept C85813293 @default.
- W2020202471 hasConcept C86803240 @default.
- W2020202471 hasConcept C93304396 @default.
- W2020202471 hasConcept C95444343 @default.
- W2020202471 hasConceptScore W2020202471C104317684 @default.
- W2020202471 hasConceptScore W2020202471C141937037 @default.
- W2020202471 hasConceptScore W2020202471C1491633281 @default.
- W2020202471 hasConceptScore W2020202471C2778354886 @default.
- W2020202471 hasConceptScore W2020202471C30481170 @default.
- W2020202471 hasConceptScore W2020202471C45472230 @default.
- W2020202471 hasConceptScore W2020202471C54355233 @default.
- W2020202471 hasConceptScore W2020202471C85813293 @default.