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- W2020206872 abstract "Summary 1- p -Carboxamidophenyl-3,3-dimethyltriazene required metabolic activation by liver postmitochondrial supernatant or microsomes in the presence of an NADPH generating system to exhibit cytotoxic effects in vitro. Dilution of liver 10,000 × g supernatant or microsomes, and the pretreatment of microsomes with cholic acid increased the cytotoxic effects. Under these conditions the level of oxidative N -demethylation of the drug, and presumably the production of its corresponding monomethyltriazene, were reduced. The results indicate that under the experimental conditions employed the observed metabolic activation was not entirely due to oxidative N -demethylation." @default.
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- W2020206872 title "In vitro metabolic activation of 1-p-carboxamidophenyl-3,-3-dimethyltriazene to cytotoxic products" @default.
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- W2020206872 doi "https://doi.org/10.1016/s0304-3835(77)96285-1" @default.
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